Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093266546> ?p ?o ?g. }
- W3093266546 endingPage "4679" @default.
- W3093266546 startingPage "4679" @default.
- W3093266546 abstract "Transition metal-based compounds have shown promising uses as therapeutic agents. Among their unique characteristics, these compounds are suitable for interaction with specific biological targets, making them important potential drugs to treat various diseases. Copper compounds, of which Casiopeinas® are an excellent example, have shown promising results as alternatives to current cancer therapies, in part because of their intercalative properties with DNA. Vanadium compounds have been extensively studied for their pharmacological properties and application, mostly in diabetes, although recently, there is a growing interest in testing their activity as anti-cancer agents. In the present work, two compounds, [Cu(Metf)(bipy)Cl]Cl·2H2O and [Cu(Impy)(Gly)(H2O)]VO3, were obtained and characterized by visible and FTIR spectroscopies, single-crystal X-ray diffraction, and theoretical methods. The structural and electronic properties of the compounds were calculated through the density functional theory (DFT) using the Austin–Frisch–Petersson functional with dispersion APFD, and the 6-311 + G(2d,p) basis set. Non-covalent interactions were analyzed using Hirshfeld surface analysis (HSA) and atom in molecules analysis (AIM). Additionally, docking analysis to test DNA/RNA interactions with the Casiopeina-like complexes were carried out. The compounds provide metals that can interact with critical biological targets. In addition, they show interesting non-covalent interactions that are responsible for their supramolecular arrangements." @default.
- W3093266546 created "2020-10-22" @default.
- W3093266546 creator A5042310577 @default.
- W3093266546 creator A5047835151 @default.
- W3093266546 creator A5050760664 @default.
- W3093266546 creator A5053211689 @default.
- W3093266546 creator A5057642744 @default.
- W3093266546 creator A5069031998 @default.
- W3093266546 creator A5073774082 @default.
- W3093266546 creator A5091440714 @default.
- W3093266546 date "2020-10-14" @default.
- W3093266546 modified "2023-10-17" @default.
- W3093266546 title "Synthesis, Crystal Structure, and Computational Methods of Vanadium and Copper Compounds as Potential Drugs for Cancer Treatment" @default.
- W3093266546 cites W1595094981 @default.
- W3093266546 cites W1603675492 @default.
- W3093266546 cites W1847903160 @default.
- W3093266546 cites W1964427311 @default.
- W3093266546 cites W1966235871 @default.
- W3093266546 cites W1969360633 @default.
- W3093266546 cites W1978301859 @default.
- W3093266546 cites W1978966918 @default.
- W3093266546 cites W1979368277 @default.
- W3093266546 cites W1981708104 @default.
- W3093266546 cites W1982199500 @default.
- W3093266546 cites W1983790387 @default.
- W3093266546 cites W1984883623 @default.
- W3093266546 cites W1986499818 @default.
- W3093266546 cites W1990338414 @default.
- W3093266546 cites W1994186559 @default.
- W3093266546 cites W2000982551 @default.
- W3093266546 cites W2004922260 @default.
- W3093266546 cites W2011033166 @default.
- W3093266546 cites W2012488984 @default.
- W3093266546 cites W2018085478 @default.
- W3093266546 cites W2019932858 @default.
- W3093266546 cites W2019978452 @default.
- W3093266546 cites W2020775500 @default.
- W3093266546 cites W2029867653 @default.
- W3093266546 cites W2030775042 @default.
- W3093266546 cites W2038450491 @default.
- W3093266546 cites W2040527477 @default.
- W3093266546 cites W2041212814 @default.
- W3093266546 cites W2043995349 @default.
- W3093266546 cites W2044432674 @default.
- W3093266546 cites W2056089554 @default.
- W3093266546 cites W2059205366 @default.
- W3093266546 cites W2060028005 @default.
- W3093266546 cites W2064899900 @default.
- W3093266546 cites W2074060550 @default.
- W3093266546 cites W2089670424 @default.
- W3093266546 cites W2089889650 @default.
- W3093266546 cites W2090689757 @default.
- W3093266546 cites W2093084777 @default.
- W3093266546 cites W2101539565 @default.
- W3093266546 cites W2103088199 @default.
- W3093266546 cites W2105668062 @default.
- W3093266546 cites W2107790677 @default.
- W3093266546 cites W2129658137 @default.
- W3093266546 cites W2132629607 @default.
- W3093266546 cites W2132749738 @default.
- W3093266546 cites W2135373957 @default.
- W3093266546 cites W2138707441 @default.
- W3093266546 cites W2150189550 @default.
- W3093266546 cites W2158993202 @default.
- W3093266546 cites W2160425502 @default.
- W3093266546 cites W2188116750 @default.
- W3093266546 cites W2308867543 @default.
- W3093266546 cites W2317055602 @default.
- W3093266546 cites W2319564194 @default.
- W3093266546 cites W2334138351 @default.
- W3093266546 cites W2548947386 @default.
- W3093266546 cites W2591580144 @default.
- W3093266546 cites W2619350869 @default.
- W3093266546 cites W2624177752 @default.
- W3093266546 cites W2734356283 @default.
- W3093266546 cites W2752809907 @default.
- W3093266546 cites W2754572598 @default.
- W3093266546 cites W2781693661 @default.
- W3093266546 cites W2792557132 @default.
- W3093266546 cites W2809576450 @default.
- W3093266546 cites W2887855964 @default.
- W3093266546 cites W2889037271 @default.
- W3093266546 cites W2889646458 @default.
- W3093266546 cites W2897041046 @default.
- W3093266546 cites W2899066446 @default.
- W3093266546 cites W2903484580 @default.
- W3093266546 cites W2924433144 @default.
- W3093266546 cites W2943738258 @default.
- W3093266546 cites W2943945103 @default.
- W3093266546 cites W2949766441 @default.
- W3093266546 cites W2964784785 @default.
- W3093266546 cites W2969391056 @default.
- W3093266546 cites W2972178744 @default.
- W3093266546 cites W2986288126 @default.
- W3093266546 cites W2991341198 @default.
- W3093266546 cites W3001538875 @default.
- W3093266546 cites W3015768334 @default.
- W3093266546 cites W3017083093 @default.