FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093278344> ?p ?o ?g. }

• W3093278344 endingPage "7566" @default.
• W3093278344 startingPage "7566" @default.
• W3093278344 abstract "Mannan (polysaccharide) conjugated with a myelin oligodendrocyte glycoprotein (MOG) peptide, namely (KG)5MOG35–55, represents a potent and promising new approach for the immunotherapy of Multiple Sclerosis (MS). The MOG35–55 epitope conjugated with the oxidized form of mannan (poly-mannose) via a (KG)5 linker was found to inhibit the symptoms of MOG35–55-induced experimental autoimmune encephalomyelitis (EAE) in mice using prophylactic and therapeutic vaccinated protocols. Deamidation is a common modification in peptide and protein sequences, especially for Gln and Asn residues. In this study, the structural solution motif of deaminated peptides and their functional effects in an animal model for MS were explored. Several peptides based on the MOG35–55 epitope have been synthesized in which the Asn53 was replaced with Ala, Asp, or isoAsp. Our results demonstrate that the synthesized MOG peptides were formed to the deaminated products in basic conditions, and the Asn53 was mainly modified to Asp. Moreover, both peptides (wild type and deaminated derivative) conjugated with mannan (from Saccharomyces cerevisiae) independently inhibited the development of neurological symptoms and inflammatory demyelinating spinal cord lesions in MOG35–55-induced EAE. To conclude, mannan conjugated with a deamidated product did not affect the efficacy of the parent peptide." @default.
• W3093278344 created "2020-10-22" @default.
• W3093278344 creator A5000647590 @default.
• W3093278344 creator A5004399273 @default.
• W3093278344 creator A5007170413 @default.
• W3093278344 creator A5040695620 @default.
• W3093278344 creator A5050749209 @default.
• W3093278344 creator A5051713342 @default.
• W3093278344 creator A5063645480 @default.
• W3093278344 creator A5086902681 @default.
• W3093278344 date "2020-10-13" @default.
• W3093278344 modified "2023-10-18" @default.
• W3093278344 title "Characterization of Asparagine Deamidation in Immunodominant Myelin Oligodendrocyte Glycoprotein Peptide Potential Immunotherapy for the Treatment of Multiple Sclerosis" @default.
• W3093278344 cites W1607206274 @default.
• W3093278344 cites W1762414489 @default.
• W3093278344 cites W1947915931 @default.
• W3093278344 cites W1965668975 @default.
• W3093278344 cites W1967953573 @default.
• W3093278344 cites W1968037422 @default.
• W3093278344 cites W1972249283 @default.
• W3093278344 cites W1978933900 @default.
• W3093278344 cites W1989298122 @default.
• W3093278344 cites W1991806122 @default.
• W3093278344 cites W1992450378 @default.
• W3093278344 cites W1999768705 @default.
• W3093278344 cites W2014345659 @default.
• W3093278344 cites W2017129877 @default.
• W3093278344 cites W2023319785 @default.
• W3093278344 cites W2031281664 @default.
• W3093278344 cites W2031355573 @default.
• W3093278344 cites W2037116841 @default.
• W3093278344 cites W2048136530 @default.
• W3093278344 cites W2050000500 @default.
• W3093278344 cites W2056427505 @default.
• W3093278344 cites W2059226357 @default.
• W3093278344 cites W2060846993 @default.
• W3093278344 cites W2086547450 @default.
• W3093278344 cites W2090566427 @default.
• W3093278344 cites W2094026324 @default.
• W3093278344 cites W2105004789 @default.
• W3093278344 cites W2122485197 @default.
• W3093278344 cites W2123480018 @default.
• W3093278344 cites W2125068675 @default.
• W3093278344 cites W2133621763 @default.
• W3093278344 cites W2145648817 @default.
• W3093278344 cites W2151313093 @default.
• W3093278344 cites W2159004184 @default.
• W3093278344 cites W2174816172 @default.
• W3093278344 cites W2621678187 @default.
• W3093278344 cites W2724823461 @default.
• W3093278344 cites W2751535586 @default.
• W3093278344 cites W2770439000 @default.
• W3093278344 cites W2789956596 @default.
• W3093278344 cites W3104635698 @default.
• W3093278344 cites W868845294 @default.
• W3093278344 doi "https://doi.org/10.3390/ijms21207566" @default.
• W3093278344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7593956" @default.
• W3093278344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33066323" @default.
• W3093278344 hasPublicationYear "2020" @default.
• W3093278344 type Work @default.
• W3093278344 sameAs 3093278344 @default.
• W3093278344 citedByCount "5" @default.
• W3093278344 countsByYear W30932783442022 @default.
• W3093278344 countsByYear W30932783442023 @default.
• W3093278344 crossrefType "journal-article" @default.
• W3093278344 hasAuthorship W3093278344A5000647590 @default.
• W3093278344 hasAuthorship W3093278344A5004399273 @default.
• W3093278344 hasAuthorship W3093278344A5007170413 @default.
• W3093278344 hasAuthorship W3093278344A5040695620 @default.
• W3093278344 hasAuthorship W3093278344A5050749209 @default.
• W3093278344 hasAuthorship W3093278344A5051713342 @default.
• W3093278344 hasAuthorship W3093278344A5063645480 @default.
• W3093278344 hasAuthorship W3093278344A5086902681 @default.
• W3093278344 hasBestOaLocation W30932783441 @default.
• W3093278344 hasConcept C100817775 @default.
• W3093278344 hasConcept C159654299 @default.
• W3093278344 hasConcept C181199279 @default.
• W3093278344 hasConcept C185592680 @default.
• W3093278344 hasConcept C195616568 @default.
• W3093278344 hasConcept C203014093 @default.
• W3093278344 hasConcept C2778486448 @default.
• W3093278344 hasConcept C2779281246 @default.
• W3093278344 hasConcept C2779357208 @default.
• W3093278344 hasConcept C2779719659 @default.
• W3093278344 hasConcept C2780640218 @default.
• W3093278344 hasConcept C2780784506 @default.
• W3093278344 hasConcept C55493867 @default.
• W3093278344 hasConcept C86803240 @default.
• W3093278344 hasConceptScore W3093278344C100817775 @default.
• W3093278344 hasConceptScore W3093278344C159654299 @default.
• W3093278344 hasConceptScore W3093278344C181199279 @default.
• W3093278344 hasConceptScore W3093278344C185592680 @default.
• W3093278344 hasConceptScore W3093278344C195616568 @default.
• W3093278344 hasConceptScore W3093278344C203014093 @default.
• W3093278344 hasConceptScore W3093278344C2778486448 @default.
• W3093278344 hasConceptScore W3093278344C2779281246 @default.
• W3093278344 hasConceptScore W3093278344C2779357208 @default.
• W3093278344 hasConceptScore W3093278344C2779719659 @default.

• next