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• W3093278439 abstract "To quantify the histopathologic heterogeneity of testicular biopsies from non-obstructive azoospermic (NOA) men undergoing microsurgical testicular sperm extraction (mTESE). Retrospective study of prospectively collected data. All patients undergoing mTESE by a high-volume surgeon at Weill Cornell in New York City between 2010 and 2019 were evaluated. Testicular histopathology from all men were reviewed. Men were included if testicular biopsy histopathology reported by the pathologist described the percentage breakdown of respective histopathologies. Men who had pathology reports without a percentage breakdown were excluded. Descriptive reports of pathology totals were reported. A total of 971 men were included. The median age was 34 (IQR 30-39). Mean pathological components (Table 1) were 57.9 ± 42.9% Sertoli-Cell Only (SCO), 16.3 ± 32.6% maturation arrest (MA), 14.6 ± 25.28% tubular atrophy (TA), 8.0 ± 24.2% full spermatogenesis (SG), and 1.54 ± 8.6% germ cells (GC). A total of 411 (42.5%) had only one pathology on biopsy, 384 (39.8%) two different pathologies on biopsy, 171 (17.7%) had three or more different pathologies. Sperm retrieval rates for first time retrieval was 135/395 (34.2%) for one pathology in comparison to 246/486 (50.6%) with mixed patterns, with increasing rates of success with increasing pathologic variety. Of those with two pathologies, the most common pairs included SCO and TA (n=270, 74.7%) of which mean SCO component was 71.08 ± 29.10% and 28.26 ± 28.60% was TA, followed by MA and TA (n=26, 6.8%). Of those with three different pathologies, the most common combinations include SCO, MA and TA (n=37, 36.3%), of which mean SCO was 35.19 ± 28.38%, mean MA was 32.30 ± 31.20% and TA was 30.78 ± 24.51%, followed by MA, SG, and TA (n=23, 22.5%). Among men with KS (n=107), pathological components were 56.8 ± 48.3% Sertoli-Cell Only, 0.4 ± 2.3% maturation arrest, 0.6 ± 3.2% spermatogenesis, 33.6 ± 35.8% tubular atrophy, 0.52 ± 2.9% germ cells. For those with AZF mutations (n=17) pathological components were 53.2 ± 49.5% Sertoli-Cell Only, 38.8 ± 48.1% maturation arrest, 0.0 ± 0.0% spermatogenesis, 1.5 ± 3.4% tubular atrophy, and 6.5 ± 24.2% germ cells. To the best of our knowledge, this is the first report describing the pathological breakdown of testicular histopathology in a large subset of NOA men. The most common overall pathology is SCO in our cohort, which was also the most common in KS and AZF deleted men.Table 1Mean Percentage Breakdown of Testicular Histopathologies in NOA MenSCOMASGTAGCOverall (n=966)57.9 ± 42.916.3 ± 32.68.0 ± 24.214.6 ± 25.31.54 ± 8.6KS (n=107)56.8 ± 48.30.4 ± 2.30.6 ± 3.233.6 ± 35.80.52 ± 2.9AZF (n=17)53.2 ± 49.538.8 ± 48.10.0 ± 0.01.5 ± 3.46.5 ±24.2 Open table in a new tab" @default.
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• W3093278439 date "2020-09-01" @default.
• W3093278439 modified "2023-09-26" @default.
• W3093278439 title "QUANTIFYING HETEROGENEITY OF TESTICULAR HISTOPATHOLOGY IN NON-OBSTRUCTIVE AZOOSPERMIC MEN" @default.
• W3093278439 doi "https://doi.org/10.1016/j.fertnstert.2020.08.127" @default.
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