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- W3093303864 endingPage "7624" @default.
- W3093303864 startingPage "7624" @default.
- W3093303864 abstract "Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis. Cadherins are inseparably connected with catenins, forming cadherin-catenin complexes, which are crucial for cell-to-cell adherence. Any dysfunction or destabilization of cadherin-catenin complex may result in tumor progression. Epithelial mesenchymal transition (EMT) is a mechanism in which epithelial cadherin (E-cadherin) expression is lost during tumor progression. However, during tumorigenesis, many processes take place, and downregulation of E-cadherin, nuclear β-catenin and p120 catenin (p120) signaling are among the most critical. Additional signaling pathways, such as Receptor tyrosine kinase (RTK), Rho GTPases, phosphoinositide 3-kinase (PI3K) and Hippo affect cadherin cell-cell adhesion and also contribute to tumor progression and metastasis. Many signaling pathways may be activated during tumorigenesis; thus, cadherin-targeting drugs seem to limit the progression of malignant tumor. This review discusses the role of cadherins in selected signaling mechanisms involved in tumor growth. The clinical importance of cadherin will be discussed in cases of human and animal cancers." @default.
- W3093303864 created "2020-10-22" @default.
- W3093303864 creator A5013686825 @default.
- W3093303864 creator A5041486037 @default.
- W3093303864 creator A5050281708 @default.
- W3093303864 creator A5061330771 @default.
- W3093303864 creator A5063074729 @default.
- W3093303864 creator A5080748231 @default.
- W3093303864 date "2020-10-15" @default.
- W3093303864 modified "2023-10-16" @default.
- W3093303864 title "Role of Cadherins in Cancer—A Review" @default.
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