FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093328830> ?p ?o ?g. }

• W3093328830 endingPage "A479" @default.
• W3093328830 startingPage "A479" @default.
• W3093328830 abstract "SESSION TITLE: Medical Student/Resident Chest Infections Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: October 18-21, 2020 INTRODUCTION: Mucormycosis is a rare but often fatal fungal infection. These fungi are ubiquitous in nature and most commonly cause rhino-orbital-cerebral infections. Patients who are immunocompromised are at higher risk (1). CASE PRESENTATION: A 76 year-old never-smoker with a medical history significant for type 2 diabetes (HbA1c 5.8%) and Coombs negative hemolytic anemia was admitted with 3 months of progressive dyspnea. She had an associated nonproductive cough for 10 days. She denied fevers, night sweats, chest pain or hemoptysis. Two months prior to presentation, she started prednisone 60 mg daily for hemolytic anemia. Prednisone was slowly tapered to 30 mg daily at the time of presentation. She received one dose of Rituximab due to persistent anemia. Evaluation 2 weeks prior to presentation revealed a right upper lobe, 5 cm cavitary lesion on chest CT. On arrival she was tachycardic (heart rate 110) and tachypneic (respiratory rate 32) without hypoxemia. Labs were notable for a hemoglobin of 9.5 g/dl, WBC of 13.6, and creatinine of 1.85 mg/dl. Chest x-ray showed a loculated right hydropneumothorax. Chest CT showed the right hydropneumothorax with progression of the right upper lobe cavitary lesion. A 14 French pigtail catheter was placed at bedside via ultrasound guidance. Pleural studies demonstrated exudative fluid with negative cytology and cultures. She underwent CT-guided biopsy of the cavitary lesion, which revealed inflammation, necrosis, and numerous broad-ribbon-like, pauci-septate hyphae favoring mucormycosis. IV liposomal amphotericin and posaconazole were initiated. Thoracic surgery declined operative intervention due to her age and comorbidities. She developed respiratory and renal failure and passed away 1 month after presentation. DISCUSSION: This patient developed pulmonary mucormycosis in the setting of glucocorticoid and Rituximab therapy. The diagnosis of mucormycosis can be difficult due to nonspecific symptoms (1) and lack of serologic tests. Commonly used fungal antigen tests such as 1,3-beta-D-glucan are traditionally negative (2). Chest CT findings are nonspecific with the classic halo or reversed halo sign present in only a minority of cases (1). A definitive diagnosis is made with histopathology (1). Successful treatment requires early diagnosis, reversal of predisposing factors, surgical debridement, and prompt initiation of antifungal therapy (3). Liposomal amphotericin is first-line pharmacologic therapy (1); however, antifungal therapy without surgical debridement is unlikely to be successful. CONCLUSIONS: Our patient presented with an unusual case of pulmonary mucormycosis; a high suspicion and histopathology are required to make the diagnosis. CT findings are non-specific and common fungal antigen tests can be negative. Early diagnosis and prompt initiation of antifungal therapy with surgical debridement improves the chance for survival. Reference #1: Farmakiotis D, Kontoyiannis DP. Mucormycoses. Infect Dis Clin North Am 2016; 30:143. Reference #2: Ostrosky-Zeichner L, Alexander BD, Kett DH, et al. Multicenter clinical evaluation of the (1-->3) beta-D-glucan assay as an aid to diagnosis of fungal infections in humans. Clin Infect Dis 2005; 41:654. Reference #3: Spellberg B, Walsh TJ, Kontoyiannis DP, et al. Recent advances in the management of mucormycosis: from bench to bedside. Clin Infect Dis 2009; 48:1743. DISCLOSURES: No relevant relationships by Meghan Hill, source=Web Response author/editior relationship with UpToDate Please note: $5001 - $20000 Added 04/01/2020 by David Midthun, source=Web Response, value=Royalty No relevant relationships by Kelly Pennington, source=Web Response" @default.
• W3093328830 created "2020-10-22" @default.
• W3093328830 creator A5025371947 @default.
• W3093328830 creator A5060708763 @default.
• W3093328830 creator A5081212705 @default.
• W3093328830 date "2020-10-01" @default.
• W3093328830 modified "2023-09-27" @default.
• W3093328830 title "PULMONARY MUCORMYCOSIS: A RARE CAUSE OF HYDROPNEUMOTHORAX" @default.
• W3093328830 doi "https://doi.org/10.1016/j.chest.2020.08.460" @default.
• W3093328830 hasPublicationYear "2020" @default.
• W3093328830 type Work @default.
• W3093328830 sameAs 3093328830 @default.
• W3093328830 citedByCount "2" @default.
• W3093328830 countsByYear W30933288302020 @default.
• W3093328830 countsByYear W30933288302022 @default.
• W3093328830 crossrefType "journal-article" @default.
• W3093328830 hasAuthorship W3093328830A5025371947 @default.
• W3093328830 hasAuthorship W3093328830A5060708763 @default.
• W3093328830 hasAuthorship W3093328830A5081212705 @default.
• W3093328830 hasBestOaLocation W30933288301 @default.
• W3093328830 hasConcept C126838900 @default.
• W3093328830 hasConcept C141071460 @default.
• W3093328830 hasConcept C2778329176 @default.
• W3093328830 hasConcept C2778704086 @default.
• W3093328830 hasConcept C2778720950 @default.
• W3093328830 hasConcept C2779054139 @default.
• W3093328830 hasConcept C2780505380 @default.
• W3093328830 hasConcept C71924100 @default.
• W3093328830 hasConceptScore W3093328830C126838900 @default.
• W3093328830 hasConceptScore W3093328830C141071460 @default.
• W3093328830 hasConceptScore W3093328830C2778329176 @default.
• W3093328830 hasConceptScore W3093328830C2778704086 @default.
• W3093328830 hasConceptScore W3093328830C2778720950 @default.
• W3093328830 hasConceptScore W3093328830C2779054139 @default.
• W3093328830 hasConceptScore W3093328830C2780505380 @default.
• W3093328830 hasConceptScore W3093328830C71924100 @default.
• W3093328830 hasIssue "4" @default.
• W3093328830 hasLocation W30933288301 @default.
• W3093328830 hasOpenAccess W3093328830 @default.
• W3093328830 hasPrimaryLocation W30933288301 @default.
• W3093328830 hasRelatedWork W1511775759 @default.
• W3093328830 hasRelatedWork W2003938723 @default.
• W3093328830 hasRelatedWork W2047967234 @default.
• W3093328830 hasRelatedWork W2118496982 @default.
• W3093328830 hasRelatedWork W2364998975 @default.
• W3093328830 hasRelatedWork W2439875401 @default.
• W3093328830 hasRelatedWork W2981062914 @default.
• W3093328830 hasRelatedWork W4238867864 @default.
• W3093328830 hasRelatedWork W4322724051 @default.
• W3093328830 hasRelatedWork W2525756941 @default.
• W3093328830 hasVolume "158" @default.
• W3093328830 isParatext "false" @default.
• W3093328830 isRetracted "false" @default.
• W3093328830 magId "3093328830" @default.
• W3093328830 workType "article" @default.