Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093345013> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3093345013 endingPage "405" @default.
- W3093345013 startingPage "397" @default.
- W3093345013 abstract "Abstract This study was aimed to investigate the influence of verapamil‐mediated inhibition of P‐glycoprotein (P‐gp) on the pharmacokinetics of ivermectin (IVM) given orally and subcutaneously (SC) to rabbits. Twenty New Zealand rabbits were allotted to 4 groups ( n = 5) and received IVM either orally or SC (0.4 mg/kg) alone or co‐administered with verapamil (2 mg/kg SC, 3 times at a 12‐hr interval). Plasma, fecal, and urine samples were collected over 30 days after medication to assess IVM concentrations in these samples. No significant differences were observed in the pharmacokinetic parameters of IVM between oral and SC administrations. The area under the plasma concentration–time curve was higher ( p < .05) after IVM (oral)/verapamil treatment, compared with oral IVM alone. Moreover, the time to the C max of IVM was shorter ( p < .05), whereas the elimination half‐life and the mean residence time were longer ( p < .05) in the presence of verapamil. The IVM/verapamil combination administered orally or SC reduced fecal IVM concentrations, compared with IVM alone. In conclusion, the significant changes by verapamil on the pharmacokinetics of IVM, likely due to the inhibition of a P‐gp‐mediated intestinal secretion, may change IVM’s antinematodal activity." @default.
- W3093345013 created "2020-10-22" @default.
- W3093345013 creator A5029340518 @default.
- W3093345013 creator A5081637944 @default.
- W3093345013 date "2020-10-17" @default.
- W3093345013 modified "2023-09-26" @default.
- W3093345013 title "Effects of verapamil on the pharmacokinetics of ivermectin in rabbits" @default.
- W3093345013 cites W1964470226 @default.
- W3093345013 cites W1967285730 @default.
- W3093345013 cites W1975863106 @default.
- W3093345013 cites W1976054510 @default.
- W3093345013 cites W2003117375 @default.
- W3093345013 cites W2006810880 @default.
- W3093345013 cites W2008815854 @default.
- W3093345013 cites W2021443111 @default.
- W3093345013 cites W2022243311 @default.
- W3093345013 cites W2031212137 @default.
- W3093345013 cites W2035248522 @default.
- W3093345013 cites W2043206758 @default.
- W3093345013 cites W2059599623 @default.
- W3093345013 cites W2063943960 @default.
- W3093345013 cites W2077012931 @default.
- W3093345013 cites W2080862304 @default.
- W3093345013 cites W2090328645 @default.
- W3093345013 cites W2090910729 @default.
- W3093345013 cites W2097706195 @default.
- W3093345013 cites W2103467580 @default.
- W3093345013 cites W2108444850 @default.
- W3093345013 cites W2127629590 @default.
- W3093345013 cites W2135269103 @default.
- W3093345013 cites W2136393053 @default.
- W3093345013 cites W2151561498 @default.
- W3093345013 cites W2153088270 @default.
- W3093345013 cites W2159803598 @default.
- W3093345013 cites W2753834235 @default.
- W3093345013 doi "https://doi.org/10.1111/jvp.12919" @default.
- W3093345013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33070345" @default.
- W3093345013 hasPublicationYear "2020" @default.
- W3093345013 type Work @default.
- W3093345013 sameAs 3093345013 @default.
- W3093345013 citedByCount "1" @default.
- W3093345013 countsByYear W30933450132022 @default.
- W3093345013 crossrefType "journal-article" @default.
- W3093345013 hasAuthorship W3093345013A5029340518 @default.
- W3093345013 hasAuthorship W3093345013A5081637944 @default.
- W3093345013 hasConcept C112705442 @default.
- W3093345013 hasConcept C126322002 @default.
- W3093345013 hasConcept C151730666 @default.
- W3093345013 hasConcept C181389837 @default.
- W3093345013 hasConcept C185592680 @default.
- W3093345013 hasConcept C2777022698 @default.
- W3093345013 hasConcept C2777056448 @default.
- W3093345013 hasConcept C2777499811 @default.
- W3093345013 hasConcept C3020079912 @default.
- W3093345013 hasConcept C42972112 @default.
- W3093345013 hasConcept C519063684 @default.
- W3093345013 hasConcept C61716771 @default.
- W3093345013 hasConcept C71924100 @default.
- W3093345013 hasConcept C86803240 @default.
- W3093345013 hasConcept C98274493 @default.
- W3093345013 hasConceptScore W3093345013C112705442 @default.
- W3093345013 hasConceptScore W3093345013C126322002 @default.
- W3093345013 hasConceptScore W3093345013C151730666 @default.
- W3093345013 hasConceptScore W3093345013C181389837 @default.
- W3093345013 hasConceptScore W3093345013C185592680 @default.
- W3093345013 hasConceptScore W3093345013C2777022698 @default.
- W3093345013 hasConceptScore W3093345013C2777056448 @default.
- W3093345013 hasConceptScore W3093345013C2777499811 @default.
- W3093345013 hasConceptScore W3093345013C3020079912 @default.
- W3093345013 hasConceptScore W3093345013C42972112 @default.
- W3093345013 hasConceptScore W3093345013C519063684 @default.
- W3093345013 hasConceptScore W3093345013C61716771 @default.
- W3093345013 hasConceptScore W3093345013C71924100 @default.
- W3093345013 hasConceptScore W3093345013C86803240 @default.
- W3093345013 hasConceptScore W3093345013C98274493 @default.
- W3093345013 hasIssue "3" @default.
- W3093345013 hasLocation W30933450131 @default.
- W3093345013 hasOpenAccess W3093345013 @default.
- W3093345013 hasPrimaryLocation W30933450131 @default.
- W3093345013 hasRelatedWork W1555144605 @default.
- W3093345013 hasRelatedWork W1964074490 @default.
- W3093345013 hasRelatedWork W1970245702 @default.
- W3093345013 hasRelatedWork W1970331292 @default.
- W3093345013 hasRelatedWork W2001333918 @default.
- W3093345013 hasRelatedWork W2086460393 @default.
- W3093345013 hasRelatedWork W2314489661 @default.
- W3093345013 hasRelatedWork W2317627837 @default.
- W3093345013 hasRelatedWork W2414263157 @default.
- W3093345013 hasRelatedWork W2472211910 @default.
- W3093345013 hasVolume "44" @default.
- W3093345013 isParatext "false" @default.
- W3093345013 isRetracted "false" @default.
- W3093345013 magId "3093345013" @default.
- W3093345013 workType "article" @default.