FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093347575> ?p ?o ?g. }

• W3093347575 endingPage "2288" @default.
• W3093347575 startingPage "2288" @default.
• W3093347575 abstract "HepaRG cells are liver bipotent progenitors acquiring hepatocytes features when differentiated in the presence of dimethylsulfoxide (DMSO). Differentiated HepaRG (dHepaRG) are considered the best surrogate model to primary human hepatocytes (PHH) and are susceptible to several hepatotropic viruses, including Hepatitis B Virus (HBV) and Hepatitis Delta Virus (HDV) infection. Despite these advantages, HepaRG cells are not widely used for the study of these two viruses because of their long differentiation process and their rather low and variable infection rates. Here, we tested the use of a cocktail of five chemicals (5C) combined or not with DMSO to accelerate the cells’ differentiation process. We found that NTCP-mediated HDV entry and replication are similar in HepaRG cells cultivated for only 1 week with 5C and DMSO or differentiated with the regular 4-week protocol. However, even though the NTCP-mediated HBV entry process seemed similar, cccDNA and subsequent HBV replication markers were lower in HepaRG cells cultivated for 1 week with 5C and DMSO compared to the regular differentiation protocol. In conclusion, we set up a new procedure allowing fast differentiation and efficient HDV-infection of HepaRG cells and identified differential culture conditions that may allow to decipher the mechanism behind the establishment of the HBV minichromosome." @default.
• W3093347575 created "2020-10-22" @default.
• W3093347575 creator A5014745527 @default.
• W3093347575 creator A5073920591 @default.
• W3093347575 creator A5075129443 @default.
• W3093347575 creator A5091226679 @default.
• W3093347575 date "2020-10-14" @default.
• W3093347575 modified "2023-10-06" @default.
• W3093347575 title "Fast Differentiation of HepaRG Cells Allowing Hepatitis B and Delta Virus Infections" @default.
• W3093347575 cites W1009246764 @default.
• W3093347575 cites W1822042631 @default.
• W3093347575 cites W1959120593 @default.
• W3093347575 cites W1970905996 @default.
• W3093347575 cites W2027254129 @default.
• W3093347575 cites W2041007069 @default.
• W3093347575 cites W2050571266 @default.
• W3093347575 cites W2051173965 @default.
• W3093347575 cites W2075308015 @default.
• W3093347575 cites W2120426460 @default.
• W3093347575 cites W2135734424 @default.
• W3093347575 cites W2143233396 @default.
• W3093347575 cites W2149759976 @default.
• W3093347575 cites W2163574676 @default.
• W3093347575 cites W2532957036 @default.
• W3093347575 cites W2789818035 @default.
• W3093347575 cites W2817772557 @default.
• W3093347575 cites W2898195395 @default.
• W3093347575 cites W2898572616 @default.
• W3093347575 cites W2938013723 @default.
• W3093347575 cites W2941187779 @default.
• W3093347575 cites W3009935587 @default.
• W3093347575 cites W3010163084 @default.
• W3093347575 cites W3023463930 @default.
• W3093347575 cites W3025135237 @default.
• W3093347575 cites W3031283578 @default.
• W3093347575 cites W3033667838 @default.
• W3093347575 doi "https://doi.org/10.3390/cells9102288" @default.
• W3093347575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7602217" @default.
• W3093347575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33066405" @default.
• W3093347575 hasPublicationYear "2020" @default.
• W3093347575 type Work @default.
• W3093347575 sameAs 3093347575 @default.
• W3093347575 citedByCount "6" @default.
• W3093347575 countsByYear W30933475752021 @default.
• W3093347575 countsByYear W30933475752022 @default.
• W3093347575 countsByYear W30933475752023 @default.
• W3093347575 crossrefType "journal-article" @default.
• W3093347575 hasAuthorship W3093347575A5014745527 @default.
• W3093347575 hasAuthorship W3093347575A5073920591 @default.
• W3093347575 hasAuthorship W3093347575A5075129443 @default.
• W3093347575 hasAuthorship W3093347575A5091226679 @default.
• W3093347575 hasBestOaLocation W30933475751 @default.
• W3093347575 hasConcept C104317684 @default.
• W3093347575 hasConcept C140704245 @default.
• W3093347575 hasConcept C148738053 @default.
• W3093347575 hasConcept C159047783 @default.
• W3093347575 hasConcept C189490182 @default.
• W3093347575 hasConcept C201750760 @default.
• W3093347575 hasConcept C2522874641 @default.
• W3093347575 hasConcept C2777410769 @default.
• W3093347575 hasConcept C2780593183 @default.
• W3093347575 hasConcept C28328180 @default.
• W3093347575 hasConcept C54355233 @default.
• W3093347575 hasConcept C86803240 @default.
• W3093347575 hasConcept C95444343 @default.
• W3093347575 hasConceptScore W3093347575C104317684 @default.
• W3093347575 hasConceptScore W3093347575C140704245 @default.
• W3093347575 hasConceptScore W3093347575C148738053 @default.
• W3093347575 hasConceptScore W3093347575C159047783 @default.
• W3093347575 hasConceptScore W3093347575C189490182 @default.
• W3093347575 hasConceptScore W3093347575C201750760 @default.
• W3093347575 hasConceptScore W3093347575C2522874641 @default.
• W3093347575 hasConceptScore W3093347575C2777410769 @default.
• W3093347575 hasConceptScore W3093347575C2780593183 @default.
• W3093347575 hasConceptScore W3093347575C28328180 @default.
• W3093347575 hasConceptScore W3093347575C54355233 @default.
• W3093347575 hasConceptScore W3093347575C86803240 @default.
• W3093347575 hasConceptScore W3093347575C95444343 @default.
• W3093347575 hasIssue "10" @default.
• W3093347575 hasLocation W30933475751 @default.
• W3093347575 hasLocation W30933475752 @default.
• W3093347575 hasLocation W30933475753 @default.
• W3093347575 hasLocation W30933475754 @default.
• W3093347575 hasLocation W30933475755 @default.
• W3093347575 hasLocation W30933475756 @default.
• W3093347575 hasOpenAccess W3093347575 @default.
• W3093347575 hasPrimaryLocation W30933475751 @default.
• W3093347575 hasRelatedWork W1608862421 @default.
• W3093347575 hasRelatedWork W2029974800 @default.
• W3093347575 hasRelatedWork W2118787634 @default.
• W3093347575 hasRelatedWork W2140679976 @default.
• W3093347575 hasRelatedWork W2165013436 @default.
• W3093347575 hasRelatedWork W2328038080 @default.
• W3093347575 hasRelatedWork W3010999703 @default.
• W3093347575 hasRelatedWork W3140282071 @default.
• W3093347575 hasRelatedWork W3143876889 @default.
• W3093347575 hasRelatedWork W3165029026 @default.
• W3093347575 hasVolume "9" @default.

• next