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- W3093374328 abstract "The 10-23 DNAzyme is an artificially developed Mg2+ -dependent catalytic oligonucleotide that can cleave an RNA substrate in a sequence-specific fashion. In this study, new split 10-23 DNAzymes made of two nonfunctional fragments, one of which carries a boronic acid group at its 5' end, while the other has a ribonucleotide at its 3' end, were designed. Herein it is demonstrated that the addition of Mg2+ ions leads to assembly of the fragments, which in turn induces the formation of a new boronate internucleoside linkage that restores the DNAzyme activity. A systematic evaluation identified the best-performing system. The results highlight key features for efficient control of DNAzyme activity through the formation of boronate linkages." @default.
- W3093374328 created "2020-10-22" @default.
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- W3093374328 date "2020-12-15" @default.
- W3093374328 modified "2023-09-24" @default.
- W3093374328 title "Boronic Acid‐Mediated Activity Control of Split 10–23 DNAzymes" @default.
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- W3093374328 doi "https://doi.org/10.1002/chem.202004227" @default.
- W3093374328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7839725" @default.
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