FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093397456> ?p ?o ?g. }

• W3093397456 abstract "Mitochondria, heralded as the powerhouses of the cell, contain small, highly-conserved genomes. This mitochondrial DNA (mtDNA) is abundant in most eukaryotic cells, reflecting its crucial role in providing protein subunits that are necessary for oxidative phosphorylation. mtDNA is asexually transmitted through the maternal germline but the precise mechanisms that govern the maintenance of genomic integrity through the generations are still a focus of research and lively debate. The general consensus is that germline mitochondria undergo a population bottleneck and are exposed to strong purifying selection, a combination that can generate a high degree of genetic variability among offspring. Details are lacking, however, on the exact structure of the bottleneck and timing of selective pressures. Current mtDNA sequencing strategies that aim to elucidate these topics largely rely on Next Generation Sequencing (NGS) datasets that provide an abundance of data but provide no insight into mtDNA as discrete and diverse genetic elements. This research offers a high-resolution analysis of mtDNA in oocytes, with a particular focus on low-frequency variants that are often overlooked by NGS approaches but could have important clinical significance. To further enhance this whole-mtDNA genome sequencing approach, this work describes a novel sequencing strategy that couples Oxford Nanopore's long single-read capabilities with unique molecular identifiers that can generate highly accurate consensus sequences and ultimately capture the true genetic diversity of mtDNA populations.--Author's abstract" @default.
• W3093397456 created "2020-10-22" @default.
• W3093397456 creator A5083877700 @default.
• W3093397456 date "2021-01-19" @default.
• W3093397456 modified "2023-10-14" @default.
• W3093397456 title "High-resolution sequencing of mitochondrial DNA" @default.
• W3093397456 cites W1509720837 @default.
• W3093397456 cites W1996943057 @default.
• W3093397456 cites W2013588487 @default.
• W3093397456 cites W2019219052 @default.
• W3093397456 cites W2040151712 @default.
• W3093397456 cites W2071553940 @default.
• W3093397456 cites W2078487972 @default.
• W3093397456 cites W2079161571 @default.
• W3093397456 cites W2080844913 @default.
• W3093397456 cites W2095638045 @default.
• W3093397456 cites W2104269538 @default.
• W3093397456 cites W2118733092 @default.
• W3093397456 cites W2118983368 @default.
• W3093397456 cites W2120440345 @default.
• W3093397456 cites W2125995561 @default.
• W3093397456 cites W2126343030 @default.
• W3093397456 cites W2127367768 @default.
• W3093397456 cites W2137915267 @default.
• W3093397456 cites W2148746613 @default.
• W3093397456 cites W2165761834 @default.
• W3093397456 cites W2170344055 @default.
• W3093397456 cites W2328583999 @default.
• W3093397456 cites W2551880155 @default.
• W3093397456 cites W2606554480 @default.
• W3093397456 cites W2774274736 @default.
• W3093397456 cites W2791897547 @default.
• W3093397456 cites W2902201090 @default.
• W3093397456 cites W2909555475 @default.
• W3093397456 cites W2912190101 @default.
• W3093397456 cites W2913324381 @default.
• W3093397456 cites W3004462687 @default.
• W3093397456 cites W3103255766 @default.
• W3093397456 doi "https://doi.org/10.17760/d20382805" @default.
• W3093397456 hasPublicationYear "2021" @default.
• W3093397456 type Work @default.
• W3093397456 sameAs 3093397456 @default.
• W3093397456 citedByCount "0" @default.
• W3093397456 crossrefType "dissertation" @default.
• W3093397456 hasAuthorship W3093397456A5083877700 @default.
• W3093397456 hasBestOaLocation W30933974561 @default.
• W3093397456 hasConcept C104317684 @default.
• W3093397456 hasConcept C105076106 @default.
• W3093397456 hasConcept C109825262 @default.
• W3093397456 hasConcept C126513998 @default.
• W3093397456 hasConcept C141231307 @default.
• W3093397456 hasConcept C144024400 @default.
• W3093397456 hasConcept C149635348 @default.
• W3093397456 hasConcept C149923435 @default.
• W3093397456 hasConcept C180754005 @default.
• W3093397456 hasConcept C189206191 @default.
• W3093397456 hasConcept C24586158 @default.
• W3093397456 hasConcept C2780513914 @default.
• W3093397456 hasConcept C2908647359 @default.
• W3093397456 hasConcept C41008148 @default.
• W3093397456 hasConcept C51679486 @default.
• W3093397456 hasConcept C54355233 @default.
• W3093397456 hasConcept C552990157 @default.
• W3093397456 hasConcept C61320498 @default.
• W3093397456 hasConcept C70721500 @default.
• W3093397456 hasConcept C7386963 @default.
• W3093397456 hasConcept C78458016 @default.
• W3093397456 hasConcept C81977670 @default.
• W3093397456 hasConcept C86803240 @default.
• W3093397456 hasConceptScore W3093397456C104317684 @default.
• W3093397456 hasConceptScore W3093397456C105076106 @default.
• W3093397456 hasConceptScore W3093397456C109825262 @default.
• W3093397456 hasConceptScore W3093397456C126513998 @default.
• W3093397456 hasConceptScore W3093397456C141231307 @default.
• W3093397456 hasConceptScore W3093397456C144024400 @default.
• W3093397456 hasConceptScore W3093397456C149635348 @default.
• W3093397456 hasConceptScore W3093397456C149923435 @default.
• W3093397456 hasConceptScore W3093397456C180754005 @default.
• W3093397456 hasConceptScore W3093397456C189206191 @default.
• W3093397456 hasConceptScore W3093397456C24586158 @default.
• W3093397456 hasConceptScore W3093397456C2780513914 @default.
• W3093397456 hasConceptScore W3093397456C2908647359 @default.
• W3093397456 hasConceptScore W3093397456C41008148 @default.
• W3093397456 hasConceptScore W3093397456C51679486 @default.
• W3093397456 hasConceptScore W3093397456C54355233 @default.
• W3093397456 hasConceptScore W3093397456C552990157 @default.
• W3093397456 hasConceptScore W3093397456C61320498 @default.
• W3093397456 hasConceptScore W3093397456C70721500 @default.
• W3093397456 hasConceptScore W3093397456C7386963 @default.
• W3093397456 hasConceptScore W3093397456C78458016 @default.
• W3093397456 hasConceptScore W3093397456C81977670 @default.
• W3093397456 hasConceptScore W3093397456C86803240 @default.
• W3093397456 hasLocation W30933974561 @default.
• W3093397456 hasOpenAccess W3093397456 @default.
• W3093397456 hasPrimaryLocation W30933974561 @default.
• W3093397456 hasRelatedWork W1541222846 @default.
• W3093397456 hasRelatedWork W1996887960 @default.
• W3093397456 hasRelatedWork W1998741825 @default.
• W3093397456 hasRelatedWork W2019638172 @default.
• W3093397456 hasRelatedWork W2487528480 @default.

• next