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- W3093399551 endingPage "461611" @default.
- W3093399551 startingPage "461611" @default.
- W3093399551 abstract "Chiral column chromatography (CCC) is a revolutionary analytical methodology for the enantioseparation of novel positron emission tomography (PET) tracers in the primary stages of drug development. Due to the different behaviors of tracer enantiomers (e.g. toxicity, metabolism and side effects) in administrated subjects, their separation and purification is a challenging endeavor. Over the last three decades, different commercial chiral columns have been applied for the enantioseparation of PET-radioligand (PET-RL) or radiotracers (PET-RT), using high-performance liquid chromatography (HPLC). The categorization and reviewing of them is a vital topic. This review presents a brief overview of advances, applications, and future prospectives of CCC in radiopharmaceutical approaches. In addition, the effective chromatographic parameters and degravitation trends to enhance enantioseparation resolution are addressed. Moreover, the application and potential of chiral super fluidical chromatography (CSFC) as an alternative for enantioseparation in the field of radiopharmaceutical is discussed. Finally, the crucial application challenges of CCC are explained and imminent tasks are suggested." @default.
- W3093399551 created "2020-10-22" @default.
- W3093399551 creator A5059258714 @default.
- W3093399551 creator A5075626376 @default.
- W3093399551 date "2020-11-01" @default.
- W3093399551 modified "2023-10-16" @default.
- W3093399551 title "Application of chiral chromatography in radiopharmaceutical fields: A review" @default.
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