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• W3093451595 abstract "Abstract The upcoming flu season in the northern hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental co-infection of IAV with either pseudotyped or SARS-CoV-2 live virus, we found that IAV pre-infection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice co-infected with IAV in vivo . Moreover, such enhancement of SARS-CoV-2 infectivity was not seen with several other viruses probably due to a unique IAV segment as an inducer to elevate ACE2 expression. This study illustrates that IAV has a special nature to aggravate SARS-CoV-2 infection, and prevention of IAV is of great significance during the COVID-19 pandemic." @default.
• W3093451595 created "2020-10-22" @default.
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• W3093451595 date "2020-10-14" @default.
• W3093451595 modified "2023-10-01" @default.
• W3093451595 title "Co-infection of influenza A virus enhances SARS-CoV-2 infectivity" @default.
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• W3093451595 doi "https://doi.org/10.1101/2020.10.14.335893" @default.
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