FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093471214> ?p ?o ?g. }

• W3093471214 endingPage "103902" @default.
• W3093471214 startingPage "103902" @default.
• W3093471214 abstract "To date, the implications of prostaglandin I2 (PGI2), a prominent lipid mediator for modulation of immune responses, has not been clearly understood in Brucella infection. In this study, we found that cyclooxygenase-2 (COX-2) was significantly expressed in both infected bone marrow-derived macrophages (BMMs) and RAW 264.7 cells. Prostaglandin I2 synthase (PTGIS) expression was not significantly changed, and PGI2receptor (PTGIR) expression was downregulated in BMMs but upregulated in RAW 264.7 macrophages at late infection. Here, we presented that PGI2, a COX-derived metabolite, was produced by macrophages during Brucella infection and its production was regulated by COX-2 and IL-10. We suggested that PGI2 and selexipag, a potent PGI2 analogue, inhibited Brucella internalization through IP signaling which led to down-regulation of F-actin polymerization and p38α MAPK activity. Administration with selexipag suppressed immune responses and resulted in a notable reduction in bacterial burden in spleen of Brucella-challenged mice. Taken together, our study is the first to characterize PGI2 synthesis and its effect in evasion strategy of macrophages against Brucella infection." @default.
• W3093471214 created "2020-10-22" @default.
• W3093471214 creator A5015511808 @default.
• W3093471214 creator A5017518849 @default.
• W3093471214 creator A5026339029 @default.
• W3093471214 creator A5038963453 @default.
• W3093471214 creator A5058099030 @default.
• W3093471214 creator A5060437172 @default.
• W3093471214 creator A5061777240 @default.
• W3093471214 creator A5075408322 @default.
• W3093471214 date "2021-02-01" @default.
• W3093471214 modified "2023-10-17" @default.
• W3093471214 title "Prostaglandin I2 (PGI2) inhibits Brucella abortus internalization in macrophages via PGI2 receptor signaling, and its analogue affects immune response and disease outcome in mice" @default.
• W3093471214 cites W1627330887 @default.
• W3093471214 cites W1766122222 @default.
• W3093471214 cites W1841679394 @default.
• W3093471214 cites W1842582718 @default.
• W3093471214 cites W1927734345 @default.
• W3093471214 cites W1964954110 @default.
• W3093471214 cites W1969895092 @default.
• W3093471214 cites W1970512866 @default.
• W3093471214 cites W1974528343 @default.
• W3093471214 cites W1994136841 @default.
• W3093471214 cites W1994865324 @default.
• W3093471214 cites W1999791285 @default.
• W3093471214 cites W2002024993 @default.
• W3093471214 cites W2002351066 @default.
• W3093471214 cites W2004016651 @default.
• W3093471214 cites W2013648887 @default.
• W3093471214 cites W2030571587 @default.
• W3093471214 cites W2056241473 @default.
• W3093471214 cites W2067672361 @default.
• W3093471214 cites W2068594714 @default.
• W3093471214 cites W2077356424 @default.
• W3093471214 cites W2085357178 @default.
• W3093471214 cites W2101248896 @default.
• W3093471214 cites W2101768385 @default.
• W3093471214 cites W2107277218 @default.
• W3093471214 cites W2120692442 @default.
• W3093471214 cites W2125042173 @default.
• W3093471214 cites W2129935236 @default.
• W3093471214 cites W2146403616 @default.
• W3093471214 cites W2155373034 @default.
• W3093471214 cites W2166753020 @default.
• W3093471214 cites W2408310638 @default.
• W3093471214 cites W2560366268 @default.
• W3093471214 cites W2565014170 @default.
• W3093471214 cites W2608390352 @default.
• W3093471214 cites W2781912964 @default.
• W3093471214 cites W2792000953 @default.
• W3093471214 cites W2798088267 @default.
• W3093471214 cites W2801707568 @default.
• W3093471214 cites W2921806482 @default.
• W3093471214 cites W2969912372 @default.
• W3093471214 cites W2972607725 @default.
• W3093471214 doi "https://doi.org/10.1016/j.dci.2020.103902" @default.
• W3093471214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33091457" @default.
• W3093471214 hasPublicationYear "2021" @default.
• W3093471214 type Work @default.
• W3093471214 sameAs 3093471214 @default.
• W3093471214 citedByCount "9" @default.
• W3093471214 countsByYear W30934712142021 @default.
• W3093471214 countsByYear W30934712142022 @default.
• W3093471214 countsByYear W30934712142023 @default.
• W3093471214 crossrefType "journal-article" @default.
• W3093471214 hasAuthorship W3093471214A5015511808 @default.
• W3093471214 hasAuthorship W3093471214A5017518849 @default.
• W3093471214 hasAuthorship W3093471214A5026339029 @default.
• W3093471214 hasAuthorship W3093471214A5038963453 @default.
• W3093471214 hasAuthorship W3093471214A5058099030 @default.
• W3093471214 hasAuthorship W3093471214A5060437172 @default.
• W3093471214 hasAuthorship W3093471214A5061777240 @default.
• W3093471214 hasAuthorship W3093471214A5075408322 @default.
• W3093471214 hasConcept C104317684 @default.
• W3093471214 hasConcept C127561419 @default.
• W3093471214 hasConcept C134018914 @default.
• W3093471214 hasConcept C139770010 @default.
• W3093471214 hasConcept C170493617 @default.
• W3093471214 hasConcept C203014093 @default.
• W3093471214 hasConcept C2778754761 @default.
• W3093471214 hasConcept C2780664492 @default.
• W3093471214 hasConcept C2780767784 @default.
• W3093471214 hasConcept C2781429187 @default.
• W3093471214 hasConcept C502942594 @default.
• W3093471214 hasConcept C55493867 @default.
• W3093471214 hasConcept C86803240 @default.
• W3093471214 hasConcept C8891405 @default.
• W3093471214 hasConcept C89423630 @default.
• W3093471214 hasConceptScore W3093471214C104317684 @default.
• W3093471214 hasConceptScore W3093471214C127561419 @default.
• W3093471214 hasConceptScore W3093471214C134018914 @default.
• W3093471214 hasConceptScore W3093471214C139770010 @default.
• W3093471214 hasConceptScore W3093471214C170493617 @default.
• W3093471214 hasConceptScore W3093471214C203014093 @default.
• W3093471214 hasConceptScore W3093471214C2778754761 @default.
• W3093471214 hasConceptScore W3093471214C2780664492 @default.
• W3093471214 hasConceptScore W3093471214C2780767784 @default.
• W3093471214 hasConceptScore W3093471214C2781429187 @default.

• next