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• W3093521653 abstract "INTRODUCTION: Identification of prognostic factors in male patients with alcoholic cirrhosis is integral to understanding the patients’ disease severity and mortality rates. We assessed various widely-used laboratory values and comorbid conditions for male patients with alcoholic liver cirrhosis (ALC) after initial hospitalization at Carilion Clinic in southwest Virginia. These individual risk factors were then assessed for its relationship with mortality. METHODS: Carilion Clinic’s electronic medical record (EPIC) was studied to identify all alcoholic patients hospitalized for the first time with either a new or prior diagnosis of alcoholic cirrhosis from 2008 to 2016 with follow-up through June 2018. Information on demographics, comorbidities, lab values, and mortality were extracted. The cumulative risks of mortality after the first hospitalization were estimated using Kaplan-Meier curves and compared among the male population. Demographic data, lab values, and comorbidities associated with cirrhosis were assessed using multivariate Cox proportional hazard analysis to determine risk factors associated with mortality. RESULTS: We identified 247 male patients (mean 54.19 ± 13.14 years) hospitalized at Carilion Clinic with diagnosis of ALC. About 70% endorsed alcohol use at the time of admission, 10% endorsed illicit drug use, and 56% endorsed tobacco use. The 1, 3- and 5- year cumulative mortality after the first hospitalization was 43.4%, 53.2% and 61.6%, respectively. The median survival for younger male patients with ALC (age < 40 years old) after first hospitalization was statistically significant compared to the older male patients (age > 40 years) (P = 0.0009) (Figure 1). On multivariate Cox proportional hazard analysis, age > 40 years, illicit drug use, BUN levels at time of admission, creatinine levels at time of admission, INR at time of admission, albumin levels at time of admission, white blood cells at time of admission, absolute neutrophil count at time of admission, lymphocyte count at time of discharge, and INR at time of discharge were all associated with increased risk of mortality (Table 1). CONCLUSION: Several risk factors are associated with unfavorable outcomes in male patients with newly diagnosed alcoholic cirrhosis. Patients with several risk factors should be monitored aggressively and referred early for liver transplant evaluation.Table 1.: Risk Factors of Male Patients associated with Mortality in Alcoholic Liver CirrhosisFigure 1.: Mortality of Young vs. Old Male Patients with ALC after First Hospitalization." @default.
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• W3093521653 date "2020-10-01" @default.
• W3093521653 modified "2023-09-26" @default.
• W3093521653 title "S1119 Survival and Risk Factors Contributing to Mortality in Male Patients Hospitalized With Alcoholic Liver Cirrhosis" @default.
• W3093521653 doi "https://doi.org/10.14309/01.ajg.0000706524.32423.ae" @default.
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