FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093541128> ?p ?o ?g. }

• W3093541128 abstract "Depression is a major cause of disease burden and severely impairs well-being of patients around the globe. Geniposide (GP) has been revealed to play a significant role in depression treatment. Of note, RNA sequencing of this study identified highly expressed long non-coding RNA Six3os1 in response to GP treatment. Thus, we aim to explore how GP affected chronic unpredictable mild stress (CUMS)-induced depression-like behaviors in mice in vivo and in vitro and the downstream molecular mechanism related to Six3os1. The relationship of Six3os1, miR-511-3p and Fezf1 was evaluated by dual-luciferase reporter gene assay, RIP assay, and RNA pulling down assay. Ectopic expression and knockdown experiments were developed in CUMS-induced mice and neurons with or without GP treatment. In vitro experiments and behavioral tests were conducted to examine alteration of CUMS-triggered oxidative stress following different interferences. The experimental data validated that GP treatment resulted in high expression of Six3os1 and Fezf1 and poor expression of miR-511-3p in CUMS-induced neurons. Six3os1 activated the AKT signaling pathway by upregulating miR-511-3p-targeted Fezf1. Either GP treatment or overexpression of Six3os1 or Fezf1 alleviated depression-like behaviors of CUMS-induced mice. GP treatment, miR-511-3p inhibition or overexpression of Six3os1 or Fezf1 not only reduced oxidative stress in CUMS-induced mice and neurons, but also reduced CUMS-induced neuronal apoptosis. Collectively, GP treatment-mediated Six3os1 upregulation ameliorated oxidative stress of mice with depression-like behaviors via the miR-511-3p/Fezf1/AKT axis." @default.
• W3093541128 created "2020-10-29" @default.
• W3093541128 creator A5002278105 @default.
• W3093541128 creator A5009582070 @default.
• W3093541128 creator A5016908499 @default.
• W3093541128 creator A5028190971 @default.
• W3093541128 creator A5032025930 @default.
• W3093541128 creator A5036766747 @default.
• W3093541128 creator A5048760640 @default.
• W3093541128 creator A5048817987 @default.
• W3093541128 creator A5055616913 @default.
• W3093541128 creator A5070028057 @default.
• W3093541128 date "2020-10-22" @default.
• W3093541128 modified "2023-10-16" @default.
• W3093541128 title "Geniposide Alleviates Oxidative Stress of Mice With Depression-Like Behaviors by Upregulating Six3os1" @default.
• W3093541128 cites W1116894000 @default.
• W3093541128 cites W1969124961 @default.
• W3093541128 cites W2002817157 @default.
• W3093541128 cites W2018151311 @default.
• W3093541128 cites W2023516160 @default.
• W3093541128 cites W2044672052 @default.
• W3093541128 cites W2064761981 @default.
• W3093541128 cites W2073337147 @default.
• W3093541128 cites W2081991273 @default.
• W3093541128 cites W2087374364 @default.
• W3093541128 cites W2104143100 @default.
• W3093541128 cites W2284945385 @default.
• W3093541128 cites W2431256774 @default.
• W3093541128 cites W2462807443 @default.
• W3093541128 cites W2549177457 @default.
• W3093541128 cites W2583139546 @default.
• W3093541128 cites W2659689178 @default.
• W3093541128 cites W2738913092 @default.
• W3093541128 cites W2752304808 @default.
• W3093541128 cites W2781550717 @default.
• W3093541128 cites W2796364626 @default.
• W3093541128 cites W2799849324 @default.
• W3093541128 cites W2883515602 @default.
• W3093541128 cites W2886197851 @default.
• W3093541128 cites W2890430536 @default.
• W3093541128 cites W2891714351 @default.
• W3093541128 cites W2892973865 @default.
• W3093541128 cites W2893019408 @default.
• W3093541128 cites W2898260790 @default.
• W3093541128 cites W2901617995 @default.
• W3093541128 cites W2904778229 @default.
• W3093541128 cites W2925532910 @default.
• W3093541128 cites W2931181194 @default.
• W3093541128 cites W2945032174 @default.
• W3093541128 cites W2947067356 @default.
• W3093541128 cites W2963508697 @default.
• W3093541128 cites W2964767251 @default.
• W3093541128 cites W2966956456 @default.
• W3093541128 cites W2977895995 @default.
• W3093541128 cites W2977982362 @default.
• W3093541128 cites W803678408 @default.
• W3093541128 doi "https://doi.org/10.3389/fcell.2020.553728" @default.
• W3093541128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7642041" @default.
• W3093541128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33195189" @default.
• W3093541128 hasPublicationYear "2020" @default.
• W3093541128 type Work @default.
• W3093541128 sameAs 3093541128 @default.
• W3093541128 citedByCount "18" @default.
• W3093541128 countsByYear W30935411282021 @default.
• W3093541128 countsByYear W30935411282022 @default.
• W3093541128 countsByYear W30935411282023 @default.
• W3093541128 crossrefType "journal-article" @default.
• W3093541128 hasAuthorship W3093541128A5002278105 @default.
• W3093541128 hasAuthorship W3093541128A5009582070 @default.
• W3093541128 hasAuthorship W3093541128A5016908499 @default.
• W3093541128 hasAuthorship W3093541128A5028190971 @default.
• W3093541128 hasAuthorship W3093541128A5032025930 @default.
• W3093541128 hasAuthorship W3093541128A5036766747 @default.
• W3093541128 hasAuthorship W3093541128A5048760640 @default.
• W3093541128 hasAuthorship W3093541128A5048817987 @default.
• W3093541128 hasAuthorship W3093541128A5055616913 @default.
• W3093541128 hasAuthorship W3093541128A5070028057 @default.
• W3093541128 hasBestOaLocation W30935411281 @default.
• W3093541128 hasConcept C104317684 @default.
• W3093541128 hasConcept C127561419 @default.
• W3093541128 hasConcept C134018914 @default.
• W3093541128 hasConcept C150903083 @default.
• W3093541128 hasConcept C173396325 @default.
• W3093541128 hasConcept C185592680 @default.
• W3093541128 hasConcept C190283241 @default.
• W3093541128 hasConcept C202751555 @default.
• W3093541128 hasConcept C207001950 @default.
• W3093541128 hasConcept C2776151105 @default.
• W3093541128 hasConcept C55493867 @default.
• W3093541128 hasConcept C62478195 @default.
• W3093541128 hasConcept C71924100 @default.
• W3093541128 hasConcept C75217442 @default.
• W3093541128 hasConcept C86803240 @default.
• W3093541128 hasConcept C95444343 @default.
• W3093541128 hasConcept C97037327 @default.
• W3093541128 hasConcept C98274493 @default.
• W3093541128 hasConceptScore W3093541128C104317684 @default.
• W3093541128 hasConceptScore W3093541128C127561419 @default.
• W3093541128 hasConceptScore W3093541128C134018914 @default.
• W3093541128 hasConceptScore W3093541128C150903083 @default.

• next