FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093546604> ?p ?o ?g. }

• W3093546604 endingPage "e0239561" @default.
• W3093546604 startingPage "e0239561" @default.
• W3093546604 abstract "Pulmonary hypertension and cor pulmonale are complications of severe equine asthma, as a consequence of pulmonary hypoxic vasoconstriction. However, as pulmonary hypertension is only partially reversible by oxygen administration, other etiological factors are likely involved. In human chronic obstructive pulmonary disease, pulmonary artery remodeling contributes to the development of pulmonary hypertension. In rodent models, pulmonary vascular remodeling is present as a consequence of allergic airway inflammation. The present study investigated the presence of remodeling of the pulmonary arteries in severe equine asthma, its distribution throughout the lungs, and its reversibility following long-term antigen avoidance strategies and inhaled corticosteroid administration. Using histomorphometry, the total wall area of pulmonary arteries from different regions of the lungs of asthmatic horses and controls was measured. The smooth muscle mass of pulmonary arteries was also estimated on lung sections stained for α-smooth muscle actin. Reversibility of vascular changes in asthmatic horses was assessed after 1 year of antigen avoidance alone or treatment with inhaled fluticasone. Pulmonary arteries showed increased wall area in apical and caudodorsal lung regions of asthmatic horses in both exacerbation and remission. The pulmonary arteries smooth muscle mass was similarly increased. Both treatments reversed the increase in wall area. However, a trend for normalization of the vascular smooth muscle mass was observed only after treatment with antigen avoidance, but not with fluticasone. In conclusion, severe equine asthma is associated with remodeling of the pulmonary arteries consisting in an increased smooth muscle mass. The resulting narrowing of the artery lumen could enhance hypoxic vasoconstriction, contributing to pulmonary hypertension. In our study population, the antigen avoidance strategy appeared more promising than inhaled corticosteroids in controlling vascular remodeling. However, further studies are needed to support the reversibility of vascular smooth muscle mass remodeling after asthma treatment." @default.
• W3093546604 created "2020-10-29" @default.
• W3093546604 creator A5033415494 @default.
• W3093546604 creator A5052919574 @default.
• W3093546604 creator A5053293427 @default.
• W3093546604 creator A5062460392 @default.
• W3093546604 creator A5088398346 @default.
• W3093546604 date "2020-10-22" @default.
• W3093546604 modified "2023-10-10" @default.
• W3093546604 title "Severe asthma is associated with a remodeling of the pulmonary arteries in horses" @default.
• W3093546604 cites W112896008 @default.
• W3093546604 cites W1925644828 @default.
• W3093546604 cites W1963958540 @default.
• W3093546604 cites W1972281305 @default.
• W3093546604 cites W1972653770 @default.
• W3093546604 cites W1976313659 @default.
• W3093546604 cites W1978484086 @default.
• W3093546604 cites W1978733003 @default.
• W3093546604 cites W1979129486 @default.
• W3093546604 cites W1989920522 @default.
• W3093546604 cites W1996067206 @default.
• W3093546604 cites W2001576432 @default.
• W3093546604 cites W2012789898 @default.
• W3093546604 cites W2013365104 @default.
• W3093546604 cites W2023430605 @default.
• W3093546604 cites W2025523143 @default.
• W3093546604 cites W2027838425 @default.
• W3093546604 cites W2041509987 @default.
• W3093546604 cites W2045450215 @default.
• W3093546604 cites W2048947670 @default.
• W3093546604 cites W2049610074 @default.
• W3093546604 cites W2052819862 @default.
• W3093546604 cites W2053205239 @default.
• W3093546604 cites W2070438409 @default.
• W3093546604 cites W2073316967 @default.
• W3093546604 cites W2077981472 @default.
• W3093546604 cites W2079648278 @default.
• W3093546604 cites W2088197706 @default.
• W3093546604 cites W2099540110 @default.
• W3093546604 cites W2102181775 @default.
• W3093546604 cites W2106656741 @default.
• W3093546604 cites W2107183424 @default.
• W3093546604 cites W2110817651 @default.
• W3093546604 cites W2113236035 @default.
• W3093546604 cites W2116946762 @default.
• W3093546604 cites W2120009443 @default.
• W3093546604 cites W2152896092 @default.
• W3093546604 cites W2156597171 @default.
• W3093546604 cites W2167377685 @default.
• W3093546604 cites W2175585348 @default.
• W3093546604 cites W2180591207 @default.
• W3093546604 cites W2180845934 @default.
• W3093546604 cites W2188270677 @default.
• W3093546604 cites W2205755874 @default.
• W3093546604 cites W2229142889 @default.
• W3093546604 cites W2265709122 @default.
• W3093546604 cites W2317652525 @default.
• W3093546604 cites W2342313828 @default.
• W3093546604 cites W2343934094 @default.
• W3093546604 cites W2412699772 @default.
• W3093546604 cites W2582265471 @default.
• W3093546604 cites W2750070871 @default.
• W3093546604 cites W2793537310 @default.
• W3093546604 cites W4246385924 @default.
• W3093546604 cites W4323238996 @default.
• W3093546604 doi "https://doi.org/10.1371/journal.pone.0239561" @default.
• W3093546604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7580920" @default.
• W3093546604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33091038" @default.
• W3093546604 hasPublicationYear "2020" @default.
• W3093546604 type Work @default.
• W3093546604 sameAs 3093546604 @default.
• W3093546604 citedByCount "9" @default.
• W3093546604 countsByYear W30935466042021 @default.
• W3093546604 countsByYear W30935466042022 @default.
• W3093546604 countsByYear W30935466042023 @default.
• W3093546604 crossrefType "journal-article" @default.
• W3093546604 hasAuthorship W3093546604A5033415494 @default.
• W3093546604 hasAuthorship W3093546604A5052919574 @default.
• W3093546604 hasAuthorship W3093546604A5053293427 @default.
• W3093546604 hasAuthorship W3093546604A5062460392 @default.
• W3093546604 hasAuthorship W3093546604A5088398346 @default.
• W3093546604 hasBestOaLocation W30935466041 @default.
• W3093546604 hasConcept C126322002 @default.
• W3093546604 hasConcept C164705383 @default.
• W3093546604 hasConcept C2776042228 @default.
• W3093546604 hasConcept C2777714996 @default.
• W3093546604 hasConcept C2779961880 @default.
• W3093546604 hasConcept C2780930700 @default.
• W3093546604 hasConcept C2780940725 @default.
• W3093546604 hasConcept C2780977465 @default.
• W3093546604 hasConcept C29323129 @default.
• W3093546604 hasConcept C71924100 @default.
• W3093546604 hasConcept C99322962 @default.
• W3093546604 hasConceptScore W3093546604C126322002 @default.
• W3093546604 hasConceptScore W3093546604C164705383 @default.
• W3093546604 hasConceptScore W3093546604C2776042228 @default.
• W3093546604 hasConceptScore W3093546604C2777714996 @default.
• W3093546604 hasConceptScore W3093546604C2779961880 @default.

• next