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- W3093589986 abstract "Background: Current strategies for COVID-19 therapy involve the systemic administration of drugs While pharmaceutical treatments continue to be evaluated, device-based therapies have yet to be explored We propose several transcatheter-based approaches for the treatment of COVID-19 Methods: Four transcatheter-based solutions were explored in their potential uses for COVID-19 therapy: local drug delivery, energy-based and photodynamic therapy, and neuromodulation Results: First is local, catheter-directed delivery of therapeutics directly to the lungs A localized delivery of therapeutics could increase the bioavailability of drug(s) at the site of action, in comparison to systemic delivery alone A second approach is light-based therapy Considering the antiviral, anti-inflammatory, antimicrobial, and vasculoprotective characteristics of visible light energy (380 to 750 nm), a localized, light-based catheter therapeutic approach could prove to be effective Given the distinct features of COVID-19 disease progression and its attack on hemoglobin and porphyrins, we suggest the infusion of porphyrin-based photosensitizers (PS) COVID-19 has an affinity for PS and would attach to these molecules, which would reduce hypoxic symptoms and allow for their deactivation through the photoactivation or sonoactivation of PS molecules A third approach considers that several studies have demonstrated that viruses hold electrical charges Neutralizing the charge of the virus within an electrical field is feasible to reduce the viral load using pacing wires and catheters placed near lungs A final approach is the neuromodulation of the host inflammatory response In a small preclinical study, the release of proinflammatory cytokines was reduced following transcutaneous low intensity focused ultrasound treatment of the spleen Conclusion: Several catheter-based therapies for COVID-19 were discussed It should be noted that in all approaches, the combination of a catheter-based therapy with systemic pharmaceutical therapy is recommended Robust clinical trials with clinically meaningful and relevant endpoints will be needed to assess the feasibility and safety of these approaches Categories Other: COVID-19" @default.
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- W3093589986 date "2020-10-01" @default.
- W3093589986 modified "2023-09-27" @default.
- W3093589986 title "TCT CONNECT-218 Transcatheter Therapies For COVID-19" @default.
- W3093589986 doi "https://doi.org/10.1016/j.jacc.2020.09.233" @default.
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