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- W3093614031 abstract "Hierarchical perceptual-inference models of psychosis may provide a holistic framework for understanding psychosis in schizophrenia including heterogeneity in clinical presentations. Particularly, hypothesized alterations at distinct levels of the perceptual-inference hierarchy may explain why hallucinations and delusions tend to cluster together yet sometimes manifest in isolation. To test this, we used a recently developed resting-state fMRI measure of intrinsic neural timescale (INT), which reflects the time window of neural integration and captures hierarchical brain gradients. In analyses examining extended sensory hierarchies that we first validated, we found distinct hierarchical INT alterations for hallucinations versus delusions in the auditory and somatosensory systems, thus providing support for hierarchical perceptual-inference models of psychosis. Simulations using a large-scale biophysical model suggested local elevations of excitation-inhibition ratio at different hierarchical levels as a potential mechanism. More generally, our work highlights the robustness and utility of INT for studying hierarchical processes relevant to basic and clinical neuroscience." @default.
- W3093614031 created "2020-10-29" @default.
- W3093614031 creator A5000146751 @default.
- W3093614031 creator A5036542455 @default.
- W3093614031 creator A5055811550 @default.
- W3093614031 creator A5064331706 @default.
- W3093614031 date "2020-10-27" @default.
- W3093614031 modified "2023-10-18" @default.
- W3093614031 title "Distinct hierarchical alterations of intrinsic neural timescales account for different manifestations of psychosis" @default.
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