FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093622503> ?p ?o ?g. }

• W3093622503 endingPage "805" @default.
• W3093622503 startingPage "796" @default.
• W3093622503 abstract "Culture-positive gram-negative sepsis induces greater magnitude of early innate immunity /inflammatory response compared with culture-negative sepsis. We previously demonstrated increased activation of anti-inflammatory Glucagon Like Peptide-1 (GLP-1) hormone in initial phase of sepsis more pronounced in diabetes patients. However, whether GLP-1 system is hyperactivated during the early innate immune response to gram-negative sepsis and modulated by diabetes remains unknown.Total and active GLP-1, soluble Dipeptidyl peptidase 4 (sDPP-4) enzyme, and innate immunity markers presepsin (sCD14) and procalcitonin (PCT) in plasma were determined by ELISA on admission and after 2 to 4 days in 37 adult patients with and without type 2 diabetes and gram-negative or culture-negative sepsis of different severity.Severe but not non-severe sepsis was associated with markedly increased GLP-1 system response, which correlated with PCT and the organ dysfunction marker lactate. Culture-positive gram-negative bacteria but not culture-negative sepsis induced hyper-activation of GLP-1 system, which correlated with increased innate immune markers sCD14, PCT, and lactate. GLP-1 inhibitory enzyme sDPP-4 was down regulated by sepsis and correlated negatively with sCD14 in gram-negative sepsis. Diabetic patients demonstrated increased GLP-1 response but significantly weaker innate immune response to severe and gram-negative sepsis.Early stage of gram-negative sepsis is characterized by endogenous GLP-1 system hyperactivity associated with over activation of innate immune response and organ dysfunction, which are modulated by diabetes. Total GLP-1 may be novel marker for rapid diagnosis of gram-negative sepsis and its severity." @default.
• W3093622503 created "2020-10-29" @default.
• W3093622503 creator A5000010261 @default.
• W3093622503 creator A5025756555 @default.
• W3093622503 creator A5027555383 @default.
• W3093622503 creator A5030737970 @default.
• W3093622503 creator A5030753941 @default.
• W3093622503 creator A5047334427 @default.
• W3093622503 creator A5059837027 @default.
• W3093622503 creator A5063732841 @default.
• W3093622503 creator A5072449522 @default.
• W3093622503 date "2020-10-19" @default.
• W3093622503 modified "2023-09-23" @default.
• W3093622503 title "Hyper-Activation of Endogenous GLP-1 System to Gram-negative Sepsis Is Associated With Early Innate Immune Response and Modulated by Diabetes" @default.
• W3093622503 cites W1013464767 @default.
• W3093622503 cites W1914568857 @default.
• W3093622503 cites W1995550856 @default.
• W3093622503 cites W2012941885 @default.
• W3093622503 cites W2018247592 @default.
• W3093622503 cites W2019778131 @default.
• W3093622503 cites W2041540060 @default.
• W3093622503 cites W2055611619 @default.
• W3093622503 cites W2057811513 @default.
• W3093622503 cites W2077413571 @default.
• W3093622503 cites W2080678931 @default.
• W3093622503 cites W2083831523 @default.
• W3093622503 cites W2085544415 @default.
• W3093622503 cites W2107555611 @default.
• W3093622503 cites W2116898765 @default.
• W3093622503 cites W2129261650 @default.
• W3093622503 cites W2132170562 @default.
• W3093622503 cites W2141964465 @default.
• W3093622503 cites W2142097676 @default.
• W3093622503 cites W2145577370 @default.
• W3093622503 cites W2149466293 @default.
• W3093622503 cites W2153406190 @default.
• W3093622503 cites W2163660677 @default.
• W3093622503 cites W2280404143 @default.
• W3093622503 cites W2505240827 @default.
• W3093622503 cites W2519485429 @default.
• W3093622503 cites W2554228598 @default.
• W3093622503 cites W2602843154 @default.
• W3093622503 cites W2744780151 @default.
• W3093622503 cites W2765424888 @default.
• W3093622503 cites W2768146862 @default.
• W3093622503 cites W2782837492 @default.
• W3093622503 cites W2784079987 @default.
• W3093622503 cites W2792309470 @default.
• W3093622503 cites W2803152280 @default.
• W3093622503 cites W2900848270 @default.
• W3093622503 cites W2909884569 @default.
• W3093622503 cites W2939032636 @default.
• W3093622503 cites W2960962641 @default.
• W3093622503 cites W3017855104 @default.
• W3093622503 cites W4241465166 @default.
• W3093622503 cites W744635124 @default.
• W3093622503 cites W799201662 @default.
• W3093622503 doi "https://doi.org/10.1097/shk.0000000000001683" @default.
• W3093622503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33079891" @default.
• W3093622503 hasPublicationYear "2020" @default.
• W3093622503 type Work @default.
• W3093622503 sameAs 3093622503 @default.
• W3093622503 citedByCount "5" @default.
• W3093622503 countsByYear W30936225032021 @default.
• W3093622503 countsByYear W30936225032023 @default.
• W3093622503 crossrefType "journal-article" @default.
• W3093622503 hasAuthorship W3093622503A5000010261 @default.
• W3093622503 hasAuthorship W3093622503A5025756555 @default.
• W3093622503 hasAuthorship W3093622503A5027555383 @default.
• W3093622503 hasAuthorship W3093622503A5030737970 @default.
• W3093622503 hasAuthorship W3093622503A5030753941 @default.
• W3093622503 hasAuthorship W3093622503A5047334427 @default.
• W3093622503 hasAuthorship W3093622503A5059837027 @default.
• W3093622503 hasAuthorship W3093622503A5063732841 @default.
• W3093622503 hasAuthorship W3093622503A5072449522 @default.
• W3093622503 hasConcept C134018914 @default.
• W3093622503 hasConcept C136449434 @default.
• W3093622503 hasConcept C203014093 @default.
• W3093622503 hasConcept C2778384902 @default.
• W3093622503 hasConcept C2781090800 @default.
• W3093622503 hasConcept C555293320 @default.
• W3093622503 hasConcept C71924100 @default.
• W3093622503 hasConcept C8891405 @default.
• W3093622503 hasConceptScore W3093622503C134018914 @default.
• W3093622503 hasConceptScore W3093622503C136449434 @default.
• W3093622503 hasConceptScore W3093622503C203014093 @default.
• W3093622503 hasConceptScore W3093622503C2778384902 @default.
• W3093622503 hasConceptScore W3093622503C2781090800 @default.
• W3093622503 hasConceptScore W3093622503C555293320 @default.
• W3093622503 hasConceptScore W3093622503C71924100 @default.
• W3093622503 hasConceptScore W3093622503C8891405 @default.
• W3093622503 hasIssue "6" @default.
• W3093622503 hasLocation W30936225031 @default.
• W3093622503 hasLocation W30936225032 @default.
• W3093622503 hasOpenAccess W3093622503 @default.
• W3093622503 hasPrimaryLocation W30936225031 @default.
• W3093622503 hasRelatedWork W1563850031 @default.
• W3093622503 hasRelatedWork W178181029 @default.

• next