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• W3093704180 abstract "<h2>Summary</h2> Processing in cortical circuits is driven by combinations of cortical and subcortical inputs. These inputs are often conceptually categorized as bottom-up, conveying sensory information, and top-down, conveying contextual information. Using intracellular recordings in mouse primary visual cortex, we measured neuronal responses to visual input, locomotion, and visuomotor mismatches. We show that layer 2/3 (L2/3) neurons compute a difference between top-down motor-related input and bottom-up visual flow input. Most L2/3 neurons responded to visuomotor mismatch with either hyperpolarization or depolarization, and the size of this response was correlated with distinct physiological properties. Consistent with a subtraction of bottom-up and top-down input, visual and motor-related inputs had opposing influence on L2/3 neurons. In infragranular neurons, we found no evidence of a difference computation and responses were consistent with positive integration of visuomotor inputs. Our results provide evidence that L2/3 functions as a bidirectional comparator of top-down and bottom-up input." @default.
• W3093704180 created "2020-10-29" @default.
• W3093704180 creator A5036840680 @default.
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• W3093704180 date "2020-12-01" @default.
• W3093704180 modified "2023-10-11" @default.
• W3093704180 title "Opposing Influence of Top-down and Bottom-up Input on Excitatory Layer 2/3 Neurons in Mouse Primary Visual Cortex" @default.
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• W3093704180 doi "https://doi.org/10.1016/j.neuron.2020.09.024" @default.
• W3093704180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7772056" @default.
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• W3093704180 hasPublicationYear "2020" @default.
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