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• W3093715085 abstract "Stereotactic radiosurgery (SRS) can be used to treat brain metastases (BM). However, SRS has the potential to cause neurological side effects and impair executive functioning. The purpose of this study is to evaluate motor and executive function after SRS to BM Patients treated with BM treated with SRS were followed up after 3 and 6 months with Trail Making Test (TMT) A and TMTB. TMTA measures motor function as the test involves connecting numbered circles in ascending order. TMTB also tests motor function but in addition tests executive function by requiring the subject to alternate between numbered and lettered circles in ascending order. Longer completion times indicate impairment in the respective neurocognitive domains. Statistical analysis was performed with SPSS Version 26. Mean completion times were compared with independent samples t-test. 20 participants were available for analysis of TMTA at 3 months. 2 participants were unable to complete TMTB at baseline and were excluded from TMTB analysis. Median age is 64 years (range 31 – 81 years) Mean completion times of TMTA and TMTB at baseline were 32s (range 12 – 65s) and 79s (range 25 – 170s) respectively. There was no significant difference in TMTA completion times between baseline, 3 and 6 months. Mean completion time of TMTB at 3 months are significantly shorter than at baseline (63.1s at 3 months vs 79s at baseline p = 0.009). No further significant change occurred in TMTB completion times between 3 and 6 months (p > 0.5). There was no significant difference in TMTA and B completion times between solitary vs multiple BMs and frontal vs non-frontal BMs. 75% of patients had stable brain disease at 3 months (n = 15) and at 6 months (n = 9) There is no significant change in TMTA which suggests that SRS does not cause motor deficits. Significant improvement in TMTB but not TMTA suggests improvement in executive function alone at 3 months after SRS. Improvement is likely due to the therapeutic effect of SRS on BM and symptom control as the majority of patients had stable brain disease. The frontal lobes are responsible for executive function, but there was no difference in TMTB outcomes between frontal and non-frontal BMs. We are investigating the effect of SRS-treated volume change on motor and executive function. Our study is ongoing as of January 2020 in order to recruit a larger cohort." @default.
• W3093715085 created "2020-10-29" @default.
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• W3093715085 date "2020-11-01" @default.
• W3093715085 modified "2023-09-27" @default.
• W3093715085 title "Motor and Executive Function Outcomes after Stereotactic Radiosurgery to Brain Metastases" @default.
• W3093715085 doi "https://doi.org/10.1016/j.ijrobp.2020.07.1995" @default.
• W3093715085 hasPublicationYear "2020" @default.
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