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• W3093716367 endingPage "100003" @default.
• W3093716367 startingPage "100003" @default.
• W3093716367 abstract "Unchecked large-scale rudimentary upstream (sub-merged and solid state) fermentation processes of bitter cassava roots into alcohol have often contributed significantly to agricultural wastes into environment. Thus, the study explored a proven valorisation methodology, Simultaneous Release Recovery Cyanogenesis (SRRC) along with intact bitter cassava polysaccharide-rich derivatives (CWF), as an apt to find alternative materials for food supplement excipients. Triplicate CWF powder, peeled or intact bitter cassava roots, were produced and analysed to determine critical properties suitable in tablet making. Exclusion approach, using SRRC and compaction, was performed to select desired powder properties for tablet formulation. Microcrystalline cellulose, with known properties for developing drug excipients, was used as a validation reference material. Tablets, for disintegration time and in-vitro dissolution rates studies were produced using wet-granulation, and their potential to release and bio-avail Iron-Zinc investigated in-vitro (pHs 1.2 and 6.8 solutions, 37⁰C). Morphology and Iron-Zinc dissolution-release mechanisms were examined. Kinetic models were used to describe matrix dissolution and Iron-Zinc release mechanisms. Intact root powder compaction capacity, depicted by hardness, was 4.3, 4.4 and 4.6 KG at 200, 500 and 700 MPa respectively. Scanning Electron Microscopy (SEM) showed Iron-Zinc inclusion altered tablet morphology. Efficient matrix dissolution and Iron and Zinc release were achieved, showing apex recovery efficiency (98%, 30–45 min). Fitted models well-explained dissolution and release mechanisms (mean R² = 0.95), demonstrating adequacy. SRRC-improved intact bitter cassava was confirmed as potential alternative excipient's matrix for Iron and Zinc release and bioavailability. Thus, this approach is practical for indirect waste elimination, and can promote strategy for sustainable valorisation of agricultural wastes and alternative functional food supplements delivery system." @default.
• W3093716367 created "2020-10-29" @default.
• W3093716367 creator A5058712661 @default.
• W3093716367 creator A5067803666 @default.
• W3093716367 creator A5069805360 @default.
• W3093716367 creator A5075480044 @default.
• W3093716367 creator A5083651296 @default.
• W3093716367 date "2020-09-01" @default.
• W3093716367 modified "2023-09-24" @default.
• W3093716367 title "Engineered food supplement excipients from bitter cassava for minimisation of cassava processing waste in environment" @default.
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• W3093716367 doi "https://doi.org/10.1016/j.fufo.2020.100003" @default.
• W3093716367 hasPublicationYear "2020" @default.
• W3093716367 type Work @default.

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