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- W3093719995 abstract "Significance Somatic mutations are the driving force of many age-related diseases such as cancer and hematopoietic failure. A challenge in the field is to evaluate health impact of somatic mutations prior to the appearance of disease symptoms. We describe a genetic tool named MASCOT (mosaic analysis system with Cre or Tomato) for mosaic analysis of somatic mutations that drive clonal hematopoiesis and lymphomagenesis. MASCOT can be applied to mosaic analysis of broad tissue types, and thus provides a valuable tool to aid functional dissection of somatic mutations in studies of development and disease." @default.
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- W3093719995 date "2020-10-26" @default.
- W3093719995 modified "2023-10-17" @default.
- W3093719995 title "A mosaic analysis system with Cre or Tomato expression in the mouse" @default.
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- W3093719995 doi "https://doi.org/10.1073/pnas.2014308117" @default.
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