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- W3093725611 abstract "Abstract The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread. Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogenase (PRODH) enzymes, which catalyze the last step in proline biosynthesis and the first step of its catabolism, respectively, have been extensively associated with the progression of several malignancies, and have been exposed as potential targets for anticancer drug development. As investigations into the links between proline metabolism and cancer accumulate, the complexity, and sometimes contradictory nature of this interaction emerge. It is clear that the role of proline metabolism enzymes in cancer depends on tumor type, with different cancers and cancer-related phenotypes displaying different dependencies on these enzymes. Unexpectedly, the outcome of rewiring proline metabolism also differs between conditions of nutrient and oxygen limitation. Here, we provide a comprehensive review of proline metabolism in cancer; we collate the experimental evidence that links proline metabolism with the different aspects of cancer progression and critically discuss the potential mechanisms involved." @default.
- W3093725611 created "2020-10-29" @default.
- W3093725611 creator A5005539568 @default.
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- W3093725611 creator A5087936750 @default.
- W3093725611 date "2020-10-14" @default.
- W3093725611 modified "2023-10-11" @default.
- W3093725611 title "The Janus-like role of proline metabolism in cancer" @default.
- W3093725611 cites W1522034871 @default.
- W3093725611 cites W1590075430 @default.
- W3093725611 cites W1657827244 @default.
- W3093725611 cites W1659944386 @default.
- W3093725611 cites W1913862483 @default.
- W3093725611 cites W1947561159 @default.
- W3093725611 cites W1965161721 @default.
- W3093725611 cites W1966189442 @default.
- W3093725611 cites W1966391110 @default.
- W3093725611 cites W1968261414 @default.
- W3093725611 cites W1969524738 @default.
- W3093725611 cites W1970710520 @default.
- W3093725611 cites W1974380503 @default.
- W3093725611 cites W1975517035 @default.
- W3093725611 cites W1977779928 @default.
- W3093725611 cites W1978495960 @default.
- W3093725611 cites W1980195461 @default.
- W3093725611 cites W1980771153 @default.
- W3093725611 cites W1983593669 @default.
- W3093725611 cites W1985382030 @default.
- W3093725611 cites W1987246871 @default.
- W3093725611 cites W1988518686 @default.
- W3093725611 cites W1990294254 @default.
- W3093725611 cites W1992102609 @default.
- W3093725611 cites W1993185628 @default.
- W3093725611 cites W1996183050 @default.
- W3093725611 cites W1996744811 @default.
- W3093725611 cites W1998166655 @default.
- W3093725611 cites W2000208854 @default.
- W3093725611 cites W2002885198 @default.
- W3093725611 cites W2005944449 @default.
- W3093725611 cites W2008162817 @default.
- W3093725611 cites W2009951450 @default.
- W3093725611 cites W2012834030 @default.
- W3093725611 cites W2013206354 @default.
- W3093725611 cites W2014691022 @default.
- W3093725611 cites W2015095581 @default.
- W3093725611 cites W2018179312 @default.
- W3093725611 cites W2020131167 @default.
- W3093725611 cites W2021308203 @default.
- W3093725611 cites W2022899908 @default.
- W3093725611 cites W2026630877 @default.
- W3093725611 cites W2028897202 @default.
- W3093725611 cites W2031282085 @default.
- W3093725611 cites W2034964253 @default.
- W3093725611 cites W2043395636 @default.
- W3093725611 cites W2043719434 @default.
- W3093725611 cites W2044212453 @default.
- W3093725611 cites W2047379648 @default.
- W3093725611 cites W2049667694 @default.
- W3093725611 cites W2053086993 @default.
- W3093725611 cites W2054987125 @default.
- W3093725611 cites W2055255976 @default.
- W3093725611 cites W2056103387 @default.
- W3093725611 cites W2058090336 @default.
- W3093725611 cites W2059270218 @default.
- W3093725611 cites W2061251682 @default.
- W3093725611 cites W2066808338 @default.
- W3093725611 cites W2073332412 @default.
- W3093725611 cites W2074471441 @default.
- W3093725611 cites W2074873270 @default.
- W3093725611 cites W2075698740 @default.
- W3093725611 cites W2076446882 @default.
- W3093725611 cites W2077021664 @default.
- W3093725611 cites W2077644294 @default.
- W3093725611 cites W2077657779 @default.
- W3093725611 cites W2079580613 @default.
- W3093725611 cites W2079999658 @default.
- W3093725611 cites W2080452140 @default.
- W3093725611 cites W2081060988 @default.
- W3093725611 cites W2087983575 @default.
- W3093725611 cites W2088190713 @default.
- W3093725611 cites W2090436419 @default.
- W3093725611 cites W2100610935 @default.
- W3093725611 cites W2102322990 @default.
- W3093725611 cites W2105406990 @default.
- W3093725611 cites W2106712645 @default.
- W3093725611 cites W2109831966 @default.
- W3093725611 cites W2111895881 @default.
- W3093725611 cites W2116201681 @default.
- W3093725611 cites W2117692326 @default.
- W3093725611 cites W2118936759 @default.
- W3093725611 cites W2119785831 @default.
- W3093725611 cites W2120924443 @default.
- W3093725611 cites W2125877121 @default.
- W3093725611 cites W2126817554 @default.
- W3093725611 cites W2128450196 @default.
- W3093725611 cites W2129920232 @default.