FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093727502> ?p ?o ?g. }

• W3093727502 abstract "ABSTRACT Each day, about 1012 erythrocytes and platelets are released into the blood stream. This substantial output from hematopoietic stem cells is tightly regulated by transcription factors and epigenetic modifications. Whether and how non-coding RNAs such as circular RNAs (circRNAs) contribute to the differentiation and/or identity of hematopoietic cells is to date not well understood. We recently reported a circRNA expression map of hematopoietic cells, revealing that erythrocytes and platelets contain the highest levels and numbers of circRNAs. Here, we provide the first detailed and comprehensive analysis of circRNA expression during red blood cell and megakaryocyte differentiation. CircRNA expression significantly increased during erythroid precursor differentiation into red blood cells and in differentiating megakaryocytes, in particular upon enucleation. To determine if circRNAs can modulate hematopoietic differentiation, we compared the expression levels of circRNAs and mRNAs with that of ribosomal foot printing read. This multi-omics approach revealed that only 20 out of 748 (2.6%) circRNAs associated with translation regulation of their mRNA counterparts. Furthermore, irrespective of the thousands of identified putative open reading frames in circRNAs, deep ribosome-footprinting sequencing and mass spectrometry analysis provided little evidence for translation of endogenously expressed circRNAs in erythroblasts, megakaryocytes and platelets. In conclusion, circRNAs in platelets and red blood cells are highly abundant and alter their expression profile during differentiation, yet their contribution to regulate cellular processes remains enigmatic." @default.
• W3093727502 created "2020-10-29" @default.
• W3093727502 creator A5012618942 @default.
• W3093727502 creator A5014699562 @default.
• W3093727502 creator A5036369323 @default.
• W3093727502 creator A5047576415 @default.
• W3093727502 creator A5054464664 @default.
• W3093727502 creator A5060298240 @default.
• W3093727502 creator A5087282255 @default.
• W3093727502 date "2020-10-22" @default.
• W3093727502 modified "2023-09-27" @default.
• W3093727502 title "Abundant circular RNA expression in terminal myeloid differentiation does not correlate with frequent circRNA translation, or with circRNA-mediated translation regulation" @default.
• W3093727502 cites W1916919897 @default.
• W3093727502 cites W1966411071 @default.
• W3093727502 cites W1971124929 @default.
• W3093727502 cites W1981726010 @default.
• W3093727502 cites W1991082489 @default.
• W3093727502 cites W1993529637 @default.
• W3093727502 cites W1999560226 @default.
• W3093727502 cites W2017971576 @default.
• W3093727502 cites W2023139734 @default.
• W3093727502 cites W2029664411 @default.
• W3093727502 cites W2031130939 @default.
• W3093727502 cites W2054891772 @default.
• W3093727502 cites W2058835062 @default.
• W3093727502 cites W2064165694 @default.
• W3093727502 cites W2079517684 @default.
• W3093727502 cites W2102619694 @default.
• W3093727502 cites W2109809956 @default.
• W3093727502 cites W2119488140 @default.
• W3093727502 cites W2126938291 @default.
• W3093727502 cites W2131271579 @default.
• W3093727502 cites W2136170412 @default.
• W3093727502 cites W2141708499 @default.
• W3093727502 cites W2147806662 @default.
• W3093727502 cites W2156564520 @default.
• W3093727502 cites W2157820287 @default.
• W3093727502 cites W2173562365 @default.
• W3093727502 cites W2179438025 @default.
• W3093727502 cites W2196247406 @default.
• W3093727502 cites W2279903397 @default.
• W3093727502 cites W2284415752 @default.
• W3093727502 cites W2314489585 @default.
• W3093727502 cites W2323385078 @default.
• W3093727502 cites W2524376787 @default.
• W3093727502 cites W2592811885 @default.
• W3093727502 cites W2592988313 @default.
• W3093727502 cites W2594102033 @default.
• W3093727502 cites W2597894202 @default.
• W3093727502 cites W2600581473 @default.
• W3093727502 cites W2601436215 @default.
• W3093727502 cites W2625910148 @default.
• W3093727502 cites W2744268790 @default.
• W3093727502 cites W2747157901 @default.
• W3093727502 cites W2764294957 @default.
• W3093727502 cites W2803209940 @default.
• W3093727502 cites W2910438587 @default.
• W3093727502 cites W2928515356 @default.
• W3093727502 cites W2944606734 @default.
• W3093727502 cites W2945567360 @default.
• W3093727502 cites W2948209037 @default.
• W3093727502 cites W2950605098 @default.
• W3093727502 cites W2950993016 @default.
• W3093727502 cites W2952916470 @default.
• W3093727502 cites W2965919172 @default.
• W3093727502 cites W2991384483 @default.
• W3093727502 cites W3000652483 @default.
• W3093727502 hasPublicationYear "2020" @default.
• W3093727502 type Work @default.
• W3093727502 sameAs 3093727502 @default.
• W3093727502 citedByCount "0" @default.
• W3093727502 crossrefType "posted-content" @default.
• W3093727502 hasAuthorship W3093727502A5012618942 @default.
• W3093727502 hasAuthorship W3093727502A5014699562 @default.
• W3093727502 hasAuthorship W3093727502A5036369323 @default.
• W3093727502 hasAuthorship W3093727502A5047576415 @default.
• W3093727502 hasAuthorship W3093727502A5054464664 @default.
• W3093727502 hasAuthorship W3093727502A5060298240 @default.
• W3093727502 hasAuthorship W3093727502A5087282255 @default.
• W3093727502 hasBestOaLocation W30937275021 @default.
• W3093727502 hasConcept C104317684 @default.
• W3093727502 hasConcept C105580179 @default.
• W3093727502 hasConcept C109159458 @default.
• W3093727502 hasConcept C148738053 @default.
• W3093727502 hasConcept C149364088 @default.
• W3093727502 hasConcept C153911025 @default.
• W3093727502 hasConcept C203014093 @default.
• W3093727502 hasConcept C2775893923 @default.
• W3093727502 hasConcept C2779282312 @default.
• W3093727502 hasConcept C28328180 @default.
• W3093727502 hasConcept C54355233 @default.
• W3093727502 hasConcept C67705224 @default.
• W3093727502 hasConcept C77430603 @default.
• W3093727502 hasConcept C86803240 @default.
• W3093727502 hasConcept C95444343 @default.
• W3093727502 hasConceptScore W3093727502C104317684 @default.
• W3093727502 hasConceptScore W3093727502C105580179 @default.
• W3093727502 hasConceptScore W3093727502C109159458 @default.
• W3093727502 hasConceptScore W3093727502C148738053 @default.
• W3093727502 hasConceptScore W3093727502C149364088 @default.

• next