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- W3093731347 abstract "Attachment factors and receptors are important determinants of dissemination and tropism during reovirus-induced disease. In a CRISPR cell survival screen, we discovered two genes, Cmas and Slc35a1 , which encode proteins required for sialic acid expression on the cell surface and mediate reovirus infection of microglial cells. This work elucidates host genes that render microglial cells susceptible to reovirus infection and expands current understanding of the receptors on microglial cells that are engaged by reovirus. Such knowledge may lead to new strategies to selectively target microglial cells for oncolytic applications." @default.
- W3093731347 created "2020-10-29" @default.
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- W3093731347 date "2020-12-22" @default.
- W3093731347 modified "2023-10-18" @default.
- W3093731347 title "Cytidine Monophosphate <i>N</i> -Acetylneuraminic Acid Synthetase and Solute Carrier Family 35 Member A1 Are Required for Reovirus Binding and Infection" @default.
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- W3093731347 doi "https://doi.org/10.1128/jvi.01571-20" @default.
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