FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093763647> ?p ?o ?g. }

• W3093763647 abstract "Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by progressive loss of motor neurons (MNs) and subsequent muscle weakness. These pathological features are associated with numerous cellular changes, including alteration in mitochondrial morphology and function. However, the molecular mechanisms associating mitochondrial structure with ALS pathology are poorly understood. In this study, we found that Dynamin-related protein 1 (Drp1) was dephosphorylated in several ALS models, including those with SOD1 and TDP-43 mutations, and the dephosphorylation was mediated by the pathological induction of protein phosphatase 1 (PP1) activity in these models. Suppression of the PP1-Drp1 cascade effectively prevented ALS-related symptoms, including mitochondrial fragmentation, mitochondrial complex I impairment, axonal degeneration, and cell death, in primary neuronal culture models, iPSC-derived human MNs, and zebrafish models in vivo. These results suggest that modulation of PP1-Drp1 activity may be a therapeutic target for multiple pathological features of ALS." @default.
• W3093763647 created "2020-10-29" @default.
• W3093763647 creator A5005545204 @default.
• W3093763647 creator A5016960006 @default.
• W3093763647 creator A5026428997 @default.
• W3093763647 creator A5034978105 @default.
• W3093763647 creator A5061203886 @default.
• W3093763647 creator A5070475503 @default.
• W3093763647 creator A5085375395 @default.
• W3093763647 creator A5087269096 @default.
• W3093763647 creator A5087743546 @default.
• W3093763647 creator A5088475980 @default.
• W3093763647 date "2020-10-21" @default.
• W3093763647 modified "2023-10-08" @default.
• W3093763647 title "Prevention of mitochondrial impairment by inhibition of protein phosphatase 1 activity in amyotrophic lateral sclerosis" @default.
• W3093763647 cites W1568601491 @default.
• W3093763647 cites W1638172757 @default.
• W3093763647 cites W1968767714 @default.
• W3093763647 cites W1969387798 @default.
• W3093763647 cites W1975150586 @default.
• W3093763647 cites W1979545106 @default.
• W3093763647 cites W1980879721 @default.
• W3093763647 cites W1984055483 @default.
• W3093763647 cites W1988565273 @default.
• W3093763647 cites W1989524887 @default.
• W3093763647 cites W1991660507 @default.
• W3093763647 cites W1993547586 @default.
• W3093763647 cites W1995222212 @default.
• W3093763647 cites W1999387506 @default.
• W3093763647 cites W2007035942 @default.
• W3093763647 cites W2008413323 @default.
• W3093763647 cites W2009976415 @default.
• W3093763647 cites W2030845029 @default.
• W3093763647 cites W2033797888 @default.
• W3093763647 cites W2042396829 @default.
• W3093763647 cites W2043823611 @default.
• W3093763647 cites W2045337251 @default.
• W3093763647 cites W2047509793 @default.
• W3093763647 cites W2048730719 @default.
• W3093763647 cites W2051797386 @default.
• W3093763647 cites W2051964908 @default.
• W3093763647 cites W2053071718 @default.
• W3093763647 cites W2056892555 @default.
• W3093763647 cites W2060271974 @default.
• W3093763647 cites W2064655482 @default.
• W3093763647 cites W2065018825 @default.
• W3093763647 cites W2065246627 @default.
• W3093763647 cites W2076466413 @default.
• W3093763647 cites W2077041830 @default.
• W3093763647 cites W2080802641 @default.
• W3093763647 cites W2081818708 @default.
• W3093763647 cites W2092390300 @default.
• W3093763647 cites W2105981057 @default.
• W3093763647 cites W2108091529 @default.
• W3093763647 cites W2114024001 @default.
• W3093763647 cites W2115453265 @default.
• W3093763647 cites W2123295248 @default.
• W3093763647 cites W2125501179 @default.
• W3093763647 cites W2127718436 @default.
• W3093763647 cites W2128167427 @default.
• W3093763647 cites W2138207816 @default.
• W3093763647 cites W2141097619 @default.
• W3093763647 cites W2147802916 @default.
• W3093763647 cites W2149605366 @default.
• W3093763647 cites W2150677449 @default.
• W3093763647 cites W2154945114 @default.
• W3093763647 cites W2159188744 @default.
• W3093763647 cites W2166174519 @default.
• W3093763647 cites W2167302006 @default.
• W3093763647 cites W2168681379 @default.
• W3093763647 cites W2215096491 @default.
• W3093763647 cites W2250617219 @default.
• W3093763647 cites W2472573833 @default.
• W3093763647 cites W2528746299 @default.
• W3093763647 cites W2725805506 @default.
• W3093763647 cites W2745410698 @default.
• W3093763647 cites W2746424507 @default.
• W3093763647 cites W2782203058 @default.
• W3093763647 cites W2783217206 @default.
• W3093763647 cites W2799799804 @default.
• W3093763647 cites W2804097444 @default.
• W3093763647 cites W2883463519 @default.
• W3093763647 cites W2906405981 @default.
• W3093763647 cites W2911237161 @default.
• W3093763647 cites W2945798561 @default.
• W3093763647 cites W2946246317 @default.
• W3093763647 cites W2952459265 @default.
• W3093763647 cites W2956083358 @default.
• W3093763647 cites W4293417072 @default.
• W3093763647 cites W4295135156 @default.
• W3093763647 doi "https://doi.org/10.1038/s41419-020-03102-8" @default.
• W3093763647 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7578657" @default.
• W3093763647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33087694" @default.
• W3093763647 hasPublicationYear "2020" @default.
• W3093763647 type Work @default.
• W3093763647 sameAs 3093763647 @default.
• W3093763647 citedByCount "11" @default.
• W3093763647 countsByYear W30937636472021 @default.
• W3093763647 countsByYear W30937636472022 @default.
• W3093763647 countsByYear W30937636472023 @default.

• next