Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093764729> ?p ?o ?g. }
- W3093764729 abstract "SUMMARY Presynaptic action potential spikes control neurotransmitter release and thus interneuronal communication. However, the properties and the dynamics of presynaptic spikes in the neocortex remain enigmatic because boutons in the neocortex are small and direct patch-clamp recordings have not been performed. Here we report direct recordings from boutons of neocortical pyramidal neurons and interneurons. Our data reveal rapid and large presynaptic action potentials in layer 5 neurons and fast-spiking interneurons reliably propagating into axon collaterals. For in-depth analyses we validate boutons of mature cultured neurons as models for excitatory neocortical boutons, demonstrating that the presynaptic spike amplitude was unaffected by potassium channels, homeostatic long-term plasticity, and high-frequency firing. In contrast to the stable amplitude, presynaptic spikes profoundly broadened for example during high-frequency firing in layer 5 pyramidal neurons but not in fast-spiking interneurons. Thus, our data demonstrate large presynaptic spikes and fundamental differences between excitatory and inhibitory boutons in the neocortex." @default.
- W3093764729 created "2020-10-29" @default.
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- W3093764729 date "2020-10-20" @default.
- W3093764729 modified "2023-09-25" @default.
- W3093764729 title "Large, stable spikes exhibit differential broadening in excitatory and inhibitory neocortical boutons" @default.
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- W3093764729 doi "https://doi.org/10.1101/2020.10.19.346346" @default.
- W3093764729 hasPublicationYear "2020" @default.
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