Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093767334> ?p ?o ?g. }
- W3093767334 endingPage "G29" @default.
- W3093767334 startingPage "G12" @default.
- W3093767334 abstract "The primary functions of the gastrointestinal (GI) tract are to absorb nutrients, water, and electrolytes that are essential for life. This is accompanied by the capability of the GI tract to mix ingested content to maximize absorption and effectively excrete waste material. There have been major advances in understanding intrinsic neural mechanisms involved in GI motility. This review highlights major advances over the past few decades in our understanding of colonic motor complexes (CMCs), the major intrinsic neural patterns that control GI motility. CMCs are generated by rhythmic coordinated firing of large populations of myenteric neurons. Initially, it was thought that serotonin release from the mucosa was required for CMC generation. However, careful experiments have now shown that neither the mucosa nor endogenous serotonin are required, although, evidence suggests enteroendocrine (EC) cells modulate CMCs. The frequency and extent of propagation of CMCs are highly dependent on mechanical stimuli (circumferential stretch). In summary, the isolated mouse colon emerges as a good model to investigate intrinsic mechanisms underlying colonic motility and provides an excellent preparation to explore potential therapeutic agents on colonic motility, in a highly controlled in vitro environment. In addition, during CMCs, the mouse colon facilitates investigations into the emergence of dynamic assemblies of extensive neural networks, applicable to the nervous system of different organisms." @default.
- W3093767334 created "2020-10-29" @default.
- W3093767334 creator A5024445302 @default.
- W3093767334 creator A5066126497 @default.
- W3093767334 creator A5075115655 @default.
- W3093767334 creator A5078377710 @default.
- W3093767334 date "2021-01-01" @default.
- W3093767334 modified "2023-09-27" @default.
- W3093767334 title "Advances in colonic motor complexes in mice" @default.
- W3093767334 cites W1489033370 @default.
- W3093767334 cites W1547288529 @default.
- W3093767334 cites W1547991634 @default.
- W3093767334 cites W1576727246 @default.
- W3093767334 cites W1590646073 @default.
- W3093767334 cites W1597434328 @default.
- W3093767334 cites W1612135120 @default.
- W3093767334 cites W1789694251 @default.
- W3093767334 cites W1869401664 @default.
- W3093767334 cites W1910206257 @default.
- W3093767334 cites W1965363502 @default.
- W3093767334 cites W1974208922 @default.
- W3093767334 cites W1984711986 @default.
- W3093767334 cites W1989552243 @default.
- W3093767334 cites W1992941445 @default.
- W3093767334 cites W1998060356 @default.
- W3093767334 cites W2001818691 @default.
- W3093767334 cites W2003004073 @default.
- W3093767334 cites W2008207461 @default.
- W3093767334 cites W2008326118 @default.
- W3093767334 cites W2011921211 @default.
- W3093767334 cites W2012277771 @default.
- W3093767334 cites W2015994586 @default.
- W3093767334 cites W2017028313 @default.
- W3093767334 cites W2017847856 @default.
- W3093767334 cites W2019050542 @default.
- W3093767334 cites W2020690476 @default.
- W3093767334 cites W2023272374 @default.
- W3093767334 cites W2025930431 @default.
- W3093767334 cites W2030899236 @default.
- W3093767334 cites W2033823376 @default.
- W3093767334 cites W2037979527 @default.
- W3093767334 cites W2042439021 @default.
- W3093767334 cites W2043429778 @default.
- W3093767334 cites W2044669012 @default.
- W3093767334 cites W2044801831 @default.
- W3093767334 cites W2045323481 @default.
- W3093767334 cites W2047918245 @default.
- W3093767334 cites W2048628319 @default.
- W3093767334 cites W2048863801 @default.
- W3093767334 cites W2054839301 @default.
- W3093767334 cites W2058585578 @default.
- W3093767334 cites W2063601395 @default.
- W3093767334 cites W2069248595 @default.
- W3093767334 cites W2069306062 @default.
- W3093767334 cites W2070716170 @default.
- W3093767334 cites W2078458588 @default.
- W3093767334 cites W2081353513 @default.
- W3093767334 cites W2084452297 @default.
- W3093767334 cites W2085861689 @default.
- W3093767334 cites W2087022299 @default.
- W3093767334 cites W2088538059 @default.
- W3093767334 cites W2090689091 @default.
- W3093767334 cites W2094052410 @default.
- W3093767334 cites W2094235915 @default.
- W3093767334 cites W2096698561 @default.
- W3093767334 cites W2098976206 @default.
- W3093767334 cites W2099620381 @default.
- W3093767334 cites W2107044225 @default.
- W3093767334 cites W2107225315 @default.
- W3093767334 cites W2107929132 @default.
- W3093767334 cites W2108444160 @default.
- W3093767334 cites W2111328417 @default.
- W3093767334 cites W2117296179 @default.
- W3093767334 cites W2123649103 @default.
- W3093767334 cites W2127389037 @default.
- W3093767334 cites W2132761800 @default.
- W3093767334 cites W2138621410 @default.
- W3093767334 cites W2138776263 @default.
- W3093767334 cites W2142465720 @default.
- W3093767334 cites W2150101506 @default.
- W3093767334 cites W2151533495 @default.
- W3093767334 cites W2152543558 @default.
- W3093767334 cites W2154627001 @default.
- W3093767334 cites W2163228087 @default.
- W3093767334 cites W2166941258 @default.
- W3093767334 cites W2168678503 @default.
- W3093767334 cites W2168723618 @default.
- W3093767334 cites W2169411929 @default.
- W3093767334 cites W2170405540 @default.
- W3093767334 cites W2171466949 @default.
- W3093767334 cites W2190213290 @default.
- W3093767334 cites W2234438026 @default.
- W3093767334 cites W2245801521 @default.
- W3093767334 cites W2262185345 @default.
- W3093767334 cites W2281976862 @default.
- W3093767334 cites W2290381169 @default.
- W3093767334 cites W2301096710 @default.
- W3093767334 cites W2301119123 @default.