Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093770127> ?p ?o ?g. }
- W3093770127 endingPage "2001008" @default.
- W3093770127 startingPage "2001008" @default.
- W3093770127 abstract "Clinical treatments for the repair of osteochondral defects (OCD) are merely palliative, not completely curative, and thus enormously unfulfilled challenges. With the in-depth studies of biology, medicine, materials, and engineering technology, the conception of OCD repair and regeneration should be renewed. During the past decades, many innovative tissue-engineered approaches for repairing and regenerating damaged osteochondral units have been widely explored. Various scaffold-free and scaffold-based strategies, such as monophasic, biphasic, and currently fabricated multiphasic and gradient architectures have been proposed and evaluated. Meanwhile, progenitor cells and tissue-specific cells have also been intensively investigated in vivo as well as ex vivo. Concerning bioactive factors and drugs, they have been combined with scaffolds and/or living cells, and even released in a spatiotemporally controlled manner. Although tremendous progress has been achieved, further research and development (R&D) is needed to convert preclinical outcomes into clinical applications. Here, the osteochondral unit structure, its defect classifications, and diagnosis are summarized. Commonly used clinical reparative techniques, tissue-engineered strategies, emerging 3D-bioprinting technologies, and the status of their clinical applications are discussed. Existing challenges to translation are also discussed and potential solutions for future R&D directions are proposed." @default.
- W3093770127 created "2020-10-29" @default.
- W3093770127 creator A5007227055 @default.
- W3093770127 creator A5011497949 @default.
- W3093770127 creator A5047818138 @default.
- W3093770127 creator A5048358541 @default.
- W3093770127 creator A5052343548 @default.
- W3093770127 creator A5053597612 @default.
- W3093770127 creator A5054170917 @default.
- W3093770127 creator A5086834982 @default.
- W3093770127 date "2020-10-26" @default.
- W3093770127 modified "2023-10-03" @default.
- W3093770127 title "Innovative Tissue‐Engineered Strategies for Osteochondral Defect Repair and Regeneration: Current Progress and Challenges" @default.
- W3093770127 cites W128909848 @default.
- W3093770127 cites W129201148 @default.
- W3093770127 cites W149983709 @default.
- W3093770127 cites W1541101179 @default.
- W3093770127 cites W1586130547 @default.
- W3093770127 cites W1948689584 @default.
- W3093770127 cites W1951327498 @default.
- W3093770127 cites W1966488620 @default.
- W3093770127 cites W1973886144 @default.
- W3093770127 cites W1977950302 @default.
- W3093770127 cites W1981750541 @default.
- W3093770127 cites W1982487116 @default.
- W3093770127 cites W1983617872 @default.
- W3093770127 cites W1988592246 @default.
- W3093770127 cites W1990558157 @default.
- W3093770127 cites W1991415492 @default.
- W3093770127 cites W1996732521 @default.
- W3093770127 cites W1999586693 @default.
- W3093770127 cites W2005444099 @default.
- W3093770127 cites W2009538670 @default.
- W3093770127 cites W2011038175 @default.
- W3093770127 cites W2013825234 @default.
- W3093770127 cites W2013940976 @default.
- W3093770127 cites W2020700245 @default.
- W3093770127 cites W2022675941 @default.
- W3093770127 cites W2031942183 @default.
- W3093770127 cites W2031964593 @default.
- W3093770127 cites W2032391435 @default.
- W3093770127 cites W2042065329 @default.
- W3093770127 cites W2045767667 @default.
- W3093770127 cites W2047415049 @default.
- W3093770127 cites W2049791410 @default.
- W3093770127 cites W2053402867 @default.
- W3093770127 cites W2057685431 @default.
- W3093770127 cites W2060707824 @default.
- W3093770127 cites W2064364366 @default.
- W3093770127 cites W2065230666 @default.
- W3093770127 cites W2067079430 @default.
- W3093770127 cites W2070737759 @default.
- W3093770127 cites W2073554435 @default.
- W3093770127 cites W2073694533 @default.
- W3093770127 cites W2075079425 @default.
- W3093770127 cites W2076221329 @default.
- W3093770127 cites W2080238777 @default.
- W3093770127 cites W2081101899 @default.
- W3093770127 cites W2086249560 @default.
- W3093770127 cites W2091184713 @default.
- W3093770127 cites W2091298400 @default.
- W3093770127 cites W2093784182 @default.
- W3093770127 cites W2101408280 @default.
- W3093770127 cites W2102107183 @default.
- W3093770127 cites W2102732442 @default.
- W3093770127 cites W2103589970 @default.
- W3093770127 cites W2113457553 @default.
- W3093770127 cites W2113945572 @default.
- W3093770127 cites W2116896293 @default.
- W3093770127 cites W2121671437 @default.
- W3093770127 cites W2128748008 @default.
- W3093770127 cites W2131613126 @default.
- W3093770127 cites W2137368902 @default.
- W3093770127 cites W2139698007 @default.
- W3093770127 cites W2141153924 @default.
- W3093770127 cites W2145648976 @default.
- W3093770127 cites W2148331771 @default.
- W3093770127 cites W2159483727 @default.
- W3093770127 cites W2161915238 @default.
- W3093770127 cites W2171162651 @default.
- W3093770127 cites W2184023761 @default.
- W3093770127 cites W2187493586 @default.
- W3093770127 cites W2188584171 @default.
- W3093770127 cites W2218826205 @default.
- W3093770127 cites W2222246718 @default.
- W3093770127 cites W2236789517 @default.
- W3093770127 cites W2261578385 @default.
- W3093770127 cites W2264394731 @default.
- W3093770127 cites W2286064488 @default.
- W3093770127 cites W2286717098 @default.
- W3093770127 cites W2289348991 @default.
- W3093770127 cites W2289698725 @default.
- W3093770127 cites W2289978087 @default.
- W3093770127 cites W2295567674 @default.
- W3093770127 cites W2303185963 @default.
- W3093770127 cites W2305894515 @default.
- W3093770127 cites W2343551682 @default.
- W3093770127 cites W2362504809 @default.