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• W3093776047 abstract "Abstract Colorectal cancer is a major health problem with a significant impact on the patients' quality of life. 5‐Fluorouracil is the most common chemotherapy drug used for this type of cancer. While its molecular mechanism is the inhibition of DNA synthesis via the inhibition of thymine nucleotide synthetase, its complete anticancer mechanism is not clear. Membrane‐associated RING‐CH‐1 (MARCH1) is an E3 ubiquitin ligase that plays an important role in antigen presentation. However, MARCH1 has not been studied in the context of colorectal cancer. In this study, we demonstrated that MARCH1 is highly expressed in colorectal cancer tissues and cell lines. Furthermore, migration and invasion of colorectal tumor cells were inhibited via transfection with small interfering RNAs to suppress the expression of MARCH1. The western blot analysis showed that MARCH1 regulates epithelial–mesenchymal transition and the PI3K/AKT pathway. Moreover, 5‐fluorouracil inhibited the proliferation, migration, and invasion of tumor cells, via the targeting of MARCH1 and the consequent downregulation of the PI3K/AKT pathway, impacting the progression of epithelial–mesenchymal transition. In conclusion, our study shows that MARCH1 may play a role as an oncogene in colorectal cancer and may represent a new target molecule of 5‐fluorouracil." @default.
• W3093776047 created "2020-10-29" @default.
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• W3093776047 date "2020-10-29" @default.
• W3093776047 modified "2023-10-09" @default.
• W3093776047 title "5‐FU inhibits migration and invasion of CRC cells through PI3K/AKT pathway regulated by MARCH1" @default.
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• W3093776047 doi "https://doi.org/10.1002/cbin.11493" @default.
• W3093776047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7894547" @default.
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• W3093776047 hasPublicationYear "2020" @default.
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