FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093780069> ?p ?o ?g. }

• W3093780069 endingPage "S752" @default.
• W3093780069 startingPage "S752" @default.
• W3093780069 abstract "INTRODUCTION: Hypertriglyceridemia is a well-established cause of acute pancreatitis. Guidelines recommend using insulin and/or apheresis as treatment, however there are insufficient randomized controlled trials that demonstrate efficacy of one over the other in severely elevated triglyceride (TGL) levels. Several case reports have demonstrated the success of insulin therapy alone in treating severe levels of TGL-induced pancreatitis. In this case, we present a 29-year old male who was successfully treated with an insulin drip, who achieved goal TGL levels faster than the previously published cases. CASE DESCRIPTION/METHODS: A 29-year-old male with history of alcohol and poly-substance abuse presented to the emergency department with diffuse abdominal pain. Initial labs showed a lipase of 3970, triglyceride 8050, ALT 150, AST 152, ALP 229, Total bilirubin 1.4, direct bilirubin 0.5. A CT of the abdomen/pelvis showed peri-pancreatic fluid (image 1). A RUQ ultrasound showed no cholelithiasis and no evidence of acute cholecystitis. Patient was started on an insulin drip at 1unit/hour with D5LR. His TGL levels improved to 6050 within 12 hours, and he was maintained on the drip instead of transitioning to apheresis. By hospital day 3 his TGL levels dropped to 507 and the drip was discontinued (image 2). Hospital course was complicated by alcohol withdrawal, respiratory distress, and persistent fevers. Patient was intubated and started on Meropenem for concern over aspiration pneumonia versus necrotizing pancreatitis. A repeat CT of the abdomen/pelvis showed an edematous pancreatitis without evidence of necrosis or abscess formation. Patient was successfully treated for both pancreatitis and pneumonia, and discharged on hospital day 14 on omeprazole and fenofibrate. DISCUSSION: While TGL themselves are not toxic to the pancreas, it is their break-down into fatty-free acids by pancreatic lipase that causes toxicity. Thus, higher TGL levels confer higher risk of developing pancreatitis. In this case, patient was started quickly on an insulin drip, and his TGL decreased profoundly without need for apheresis. There have been several case reports of TGL-induced pancreatitis that were treated successfully with insulin therapy alone. However, in those cases, it took 6 days of insulin therapy until goal levels were achieved. In this presented case, goal levels were achieved by day 3.Figure 1.: Image 1.Figure 2.: Image 2." @default.
• W3093780069 created "2020-10-29" @default.
• W3093780069 creator A5040095116 @default.
• W3093780069 creator A5056008079 @default.
• W3093780069 creator A5066721337 @default.
• W3093780069 date "2020-10-01" @default.
• W3093780069 modified "2023-10-14" @default.
• W3093780069 title "S1492 Very Severe Hypertriglyceride-Induced Pancreatitis With Quick Resolution on Insulin Therapy Alone" @default.
• W3093780069 doi "https://doi.org/10.14309/01.ajg.0000708016.05205.6d" @default.
• W3093780069 hasPublicationYear "2020" @default.
• W3093780069 type Work @default.
• W3093780069 sameAs 3093780069 @default.
• W3093780069 citedByCount "0" @default.
• W3093780069 crossrefType "journal-article" @default.
• W3093780069 hasAuthorship W3093780069A5040095116 @default.
• W3093780069 hasAuthorship W3093780069A5056008079 @default.
• W3093780069 hasAuthorship W3093780069A5066721337 @default.
• W3093780069 hasBestOaLocation W30937800691 @default.
• W3093780069 hasConcept C126322002 @default.
• W3093780069 hasConcept C141071460 @default.
• W3093780069 hasConcept C2775967933 @default.
• W3093780069 hasConcept C2776670229 @default.
• W3093780069 hasConcept C2779306644 @default.
• W3093780069 hasConcept C2779983558 @default.
• W3093780069 hasConcept C71924100 @default.
• W3093780069 hasConcept C90924648 @default.
• W3093780069 hasConceptScore W3093780069C126322002 @default.
• W3093780069 hasConceptScore W3093780069C141071460 @default.
• W3093780069 hasConceptScore W3093780069C2775967933 @default.
• W3093780069 hasConceptScore W3093780069C2776670229 @default.
• W3093780069 hasConceptScore W3093780069C2779306644 @default.
• W3093780069 hasConceptScore W3093780069C2779983558 @default.
• W3093780069 hasConceptScore W3093780069C71924100 @default.
• W3093780069 hasConceptScore W3093780069C90924648 @default.
• W3093780069 hasIssue "1" @default.
• W3093780069 hasLocation W30937800691 @default.
• W3093780069 hasLocation W30937800692 @default.
• W3093780069 hasOpenAccess W3093780069 @default.
• W3093780069 hasPrimaryLocation W30937800691 @default.
• W3093780069 hasRelatedWork W1591978428 @default.
• W3093780069 hasRelatedWork W168110047 @default.
• W3093780069 hasRelatedWork W2008878688 @default.
• W3093780069 hasRelatedWork W2025988467 @default.
• W3093780069 hasRelatedWork W2144563032 @default.
• W3093780069 hasRelatedWork W2357635216 @default.
• W3093780069 hasRelatedWork W2414619174 @default.
• W3093780069 hasRelatedWork W2415871376 @default.
• W3093780069 hasRelatedWork W3119275760 @default.
• W3093780069 hasRelatedWork W2538365371 @default.
• W3093780069 hasVolume "115" @default.
• W3093780069 isParatext "false" @default.
• W3093780069 isRetracted "false" @default.
• W3093780069 magId "3093780069" @default.
• W3093780069 workType "article" @default.