Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093824384> ?p ?o ?g. }
- W3093824384 abstract "Fasciola hepatica is worldwide distributed helminth parasite that causes fasciolosis, a chronic disease affecting mainly cattle, sheep, and occasionally humans. Triclabendazole is the drug of choice. However, the continuous use of this drug has led to the development of parasite resistance and consequently the limitation of its effectiveness. Hence vaccination appears as an attractive option to develop. In this work, we evaluated the potential of F. hepatica Kunitz-type molecule (FhKTM) as antigen formulated with a liquid crystal nanostructure formed by self-assembly of 6-O-ascorbyl palmitate ester (Coa-ASC16) and the synthetic oligodeoxynucleotide containing unmethylated cytosine-guanine motifs (CpG-ODN), during an experimental model of fasciolosis in mice and we further dissected the immune response associated with host protection. Our results showed that immunization of mice with FhKTM/CpG-ODN/Coa-ASC16 induces protection against F. hepatica challenge by preventing liver damage and improving of survival after F. hepatica infection. Besides, FhKTM/CpG-ODN/Coa-ASC16-immunized mice elicited a potent IFN- and IL-17A with high levels of antigen-specific IgG1, IgG2a and IgA serum antibodies. Strikingly, IL-17A blockade during infection decreased IgG2a and IgA antibody levels as well as IFN- production, leading to an increase in mortality of vaccinated mice. The present study highlights the potential of a new vaccine formulation to improve control and help eradication of F. hepatica infection, with potential applications for natural hosts such as cattle and sheep." @default.
- W3093824384 created "2020-10-29" @default.
- W3093824384 creator A5002211520 @default.
- W3093824384 creator A5004530461 @default.
- W3093824384 creator A5030112526 @default.
- W3093824384 creator A5033794571 @default.
- W3093824384 creator A5037325520 @default.
- W3093824384 creator A5046875847 @default.
- W3093824384 creator A5053227758 @default.
- W3093824384 creator A5057229730 @default.
- W3093824384 creator A5065574048 @default.
- W3093824384 creator A5071586306 @default.
- W3093824384 creator A5080926887 @default.
- W3093824384 creator A5086266720 @default.
- W3093824384 date "2020-10-20" @default.
- W3093824384 modified "2023-10-07" @default.
- W3093824384 title "A Vaccine Based on Kunitz-Type Molecule Confers Protection Against Fasciola hepatica Challenge by Inducing IFN-γ and Antibody Immune Responses Through IL-17A Production" @default.
- W3093824384 cites W1524463420 @default.
- W3093824384 cites W1589617432 @default.
- W3093824384 cites W1968661266 @default.
- W3093824384 cites W1983263657 @default.
- W3093824384 cites W1991674225 @default.
- W3093824384 cites W1992056479 @default.
- W3093824384 cites W1997882896 @default.
- W3093824384 cites W2000719958 @default.
- W3093824384 cites W2001194497 @default.
- W3093824384 cites W2003569476 @default.
- W3093824384 cites W2004070277 @default.
- W3093824384 cites W2017666693 @default.
- W3093824384 cites W2021819399 @default.
- W3093824384 cites W2036463856 @default.
- W3093824384 cites W2044975017 @default.
- W3093824384 cites W2048354696 @default.
- W3093824384 cites W2049656155 @default.
- W3093824384 cites W2067742268 @default.
- W3093824384 cites W2071499075 @default.
- W3093824384 cites W2074302477 @default.
- W3093824384 cites W2076021329 @default.
- W3093824384 cites W2080820892 @default.
- W3093824384 cites W2083189434 @default.
- W3093824384 cites W2084375439 @default.
- W3093824384 cites W2085650393 @default.
- W3093824384 cites W2089220247 @default.
- W3093824384 cites W2091934966 @default.
- W3093824384 cites W2104161841 @default.
- W3093824384 cites W2112318395 @default.
- W3093824384 cites W2114263798 @default.
- W3093824384 cites W2116424088 @default.
- W3093824384 cites W2117384446 @default.
- W3093824384 cites W2119152811 @default.
- W3093824384 cites W2134353815 @default.
- W3093824384 cites W2146972769 @default.
- W3093824384 cites W2148567274 @default.
- W3093824384 cites W2151364373 @default.
- W3093824384 cites W2154960189 @default.
- W3093824384 cites W2193841770 @default.
- W3093824384 cites W2239789730 @default.
- W3093824384 cites W2267435392 @default.
- W3093824384 cites W2334812845 @default.
- W3093824384 cites W2344307725 @default.
- W3093824384 cites W2346561474 @default.
- W3093824384 cites W2472179141 @default.
- W3093824384 cites W2474414606 @default.
- W3093824384 cites W2500491861 @default.
- W3093824384 cites W2513324782 @default.
- W3093824384 cites W2532506217 @default.
- W3093824384 cites W2540633154 @default.
- W3093824384 cites W2568481431 @default.
- W3093824384 cites W2590758080 @default.
- W3093824384 cites W2619607443 @default.
- W3093824384 cites W2763453594 @default.
- W3093824384 cites W2770743710 @default.
- W3093824384 cites W2771581099 @default.
- W3093824384 cites W2788556314 @default.
- W3093824384 cites W2791638428 @default.
- W3093824384 cites W2805144428 @default.
- W3093824384 cites W2810021549 @default.
- W3093824384 cites W2897177126 @default.
- W3093824384 cites W2914648845 @default.
- W3093824384 cites W2979567921 @default.
- W3093824384 cites W3000074048 @default.
- W3093824384 doi "https://doi.org/10.3389/fimmu.2020.02087" @default.
- W3093824384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7641617" @default.
- W3093824384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33193292" @default.
- W3093824384 hasPublicationYear "2020" @default.
- W3093824384 type Work @default.
- W3093824384 sameAs 3093824384 @default.
- W3093824384 citedByCount "6" @default.
- W3093824384 countsByYear W30938243842021 @default.
- W3093824384 countsByYear W30938243842022 @default.
- W3093824384 countsByYear W30938243842023 @default.
- W3093824384 crossrefType "journal-article" @default.
- W3093824384 hasAuthorship W3093824384A5002211520 @default.
- W3093824384 hasAuthorship W3093824384A5004530461 @default.
- W3093824384 hasAuthorship W3093824384A5030112526 @default.
- W3093824384 hasAuthorship W3093824384A5033794571 @default.
- W3093824384 hasAuthorship W3093824384A5037325520 @default.
- W3093824384 hasAuthorship W3093824384A5046875847 @default.
- W3093824384 hasAuthorship W3093824384A5053227758 @default.
- W3093824384 hasAuthorship W3093824384A5057229730 @default.