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- W3093847179 abstract "Aim: To determine the impact of tumor sidedness on all-cause mortality for early- (age 18–49 years) and older-onset (age ≥50 years) colorectal cancer (CRC). Materials & methods: We conducted a retrospective study of 650,382 patients diagnosed with CRC between 2000 and 2016. We examined the associations of age, tumor sidedness (right colon, left colon and rectum) and all-cause mortality. Results: For early-onset CRC (n = 66,186), mortality was highest in the youngest age group (18–29 years), driven by left-sided colon cancers (vs 50–59 years, hazard ratio: 1.18; 95% CI: 1.03–1.34). 5-year risk of death among 18–29-year-olds with left-sided colon cancer (0.42, 95% CI: 0.38, 0.46) was higher than all other age groups. Conclusion: Left-sided colon cancers are enriched in younger adults and may be disproportionately fatal." @default.
- W3093847179 created "2020-10-29" @default.
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- W3093847179 date "2020-09-01" @default.
- W3093847179 modified "2023-10-14" @default.
- W3093847179 title "Early-onset colorectal cancer: more than one side to the story" @default.
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- W3093847179 doi "https://doi.org/10.2217/crc-2020-0016" @default.
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