Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093864810> ?p ?o ?g. }
- W3093864810 endingPage "108289" @default.
- W3093864810 startingPage "108289" @default.
- W3093864810 abstract "MutSα and MutSβ play important roles in DNA mismatch repair and are linked to inheritable cancers and degenerative disorders. Here, we show that MSH2 and MSH3, the two components of MutSβ, bind SLX4 protein, a scaffold for the assembly of the SLX1-SLX4-MUS81-EME1-XPF-ERCC1 (SMX) trinuclease complex. SMX promotes the resolution of Holliday junctions (HJs), which are intermediates in homologous recombinational repair. We find that MutSβ binds HJs and stimulates their resolution by SLX1-SLX4 or SMX in reactions dependent upon direct interactions between MutSβ and SLX4. In contrast, MutSα does not stimulate HJ resolution. MSH3-depleted cells exhibit reduced sister chromatid exchanges and elevated levels of homologous recombination ultrafine bridges (HR-UFBs) at mitosis, consistent with defects in the processing of recombination intermediates. These results demonstrate a role for MutSβ in addition to its established role in the pathogenic expansion of CAG/CTG trinucleotide repeats, which is causative of myotonic dystrophy and Huntington's disease." @default.
- W3093864810 created "2020-10-29" @default.
- W3093864810 creator A5020716368 @default.
- W3093864810 creator A5020915028 @default.
- W3093864810 creator A5022376007 @default.
- W3093864810 creator A5041750546 @default.
- W3093864810 creator A5054117046 @default.
- W3093864810 creator A5056095611 @default.
- W3093864810 creator A5063904644 @default.
- W3093864810 creator A5075154957 @default.
- W3093864810 date "2020-10-01" @default.
- W3093864810 modified "2023-10-11" @default.
- W3093864810 title "MutSβ Stimulates Holliday Junction Resolution by the SMX Complex" @default.
- W3093864810 cites W119100554 @default.
- W3093864810 cites W1717950015 @default.
- W3093864810 cites W1795141977 @default.
- W3093864810 cites W1808263692 @default.
- W3093864810 cites W1867215437 @default.
- W3093864810 cites W1964369692 @default.
- W3093864810 cites W1964616851 @default.
- W3093864810 cites W1965749659 @default.
- W3093864810 cites W1965993208 @default.
- W3093864810 cites W1970069044 @default.
- W3093864810 cites W1972018037 @default.
- W3093864810 cites W1973211150 @default.
- W3093864810 cites W1973674463 @default.
- W3093864810 cites W1977284533 @default.
- W3093864810 cites W1977909744 @default.
- W3093864810 cites W1980462742 @default.
- W3093864810 cites W1980830652 @default.
- W3093864810 cites W1985398661 @default.
- W3093864810 cites W1987146639 @default.
- W3093864810 cites W1988052396 @default.
- W3093864810 cites W1990321138 @default.
- W3093864810 cites W1995515648 @default.
- W3093864810 cites W1998817763 @default.
- W3093864810 cites W1999660230 @default.
- W3093864810 cites W1999728541 @default.
- W3093864810 cites W2000393605 @default.
- W3093864810 cites W2007988428 @default.
- W3093864810 cites W2011139344 @default.
- W3093864810 cites W2013655874 @default.
- W3093864810 cites W2016286342 @default.
- W3093864810 cites W2016648136 @default.
- W3093864810 cites W2021536045 @default.
- W3093864810 cites W2021717224 @default.
- W3093864810 cites W2024073282 @default.
- W3093864810 cites W2026802661 @default.
- W3093864810 cites W2026920658 @default.
- W3093864810 cites W2032097800 @default.
- W3093864810 cites W2043051674 @default.
- W3093864810 cites W2043101035 @default.
- W3093864810 cites W2044884266 @default.
- W3093864810 cites W2047433802 @default.
- W3093864810 cites W2052522374 @default.
- W3093864810 cites W2052626813 @default.
- W3093864810 cites W2054168167 @default.
- W3093864810 cites W2054875504 @default.
- W3093864810 cites W2055993339 @default.
- W3093864810 cites W2057211837 @default.
- W3093864810 cites W2062124403 @default.
- W3093864810 cites W2064700784 @default.
- W3093864810 cites W2066436688 @default.
- W3093864810 cites W2069025904 @default.
- W3093864810 cites W2069689352 @default.
- W3093864810 cites W2070781513 @default.
- W3093864810 cites W2074535394 @default.
- W3093864810 cites W2075182125 @default.
- W3093864810 cites W2075637141 @default.
- W3093864810 cites W2078319055 @default.
- W3093864810 cites W2079027867 @default.
- W3093864810 cites W2079185082 @default.
- W3093864810 cites W2082447947 @default.
- W3093864810 cites W2087634145 @default.
- W3093864810 cites W2088522869 @default.
- W3093864810 cites W2092343194 @default.
- W3093864810 cites W2094983671 @default.
- W3093864810 cites W2104003823 @default.
- W3093864810 cites W2113678351 @default.
- W3093864810 cites W2123869131 @default.
- W3093864810 cites W2126892015 @default.
- W3093864810 cites W2127305172 @default.
- W3093864810 cites W2134420941 @default.
- W3093864810 cites W2137334007 @default.
- W3093864810 cites W2137452601 @default.
- W3093864810 cites W2137655134 @default.
- W3093864810 cites W2141323033 @default.
- W3093864810 cites W2141425812 @default.
- W3093864810 cites W2149045141 @default.
- W3093864810 cites W2150583704 @default.
- W3093864810 cites W2158622145 @default.
- W3093864810 cites W2160393299 @default.
- W3093864810 cites W2165371679 @default.
- W3093864810 cites W2166911703 @default.
- W3093864810 cites W2167121797 @default.
- W3093864810 cites W2170472485 @default.
- W3093864810 cites W2198940593 @default.
- W3093864810 cites W2201351708 @default.