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• W3093871736 abstract "Tissue transglutaminase (TG2) is a multifunctional protein that can act as a cross-linking enzyme, GTPase/ATPase, protein kinase, and protein disulfide isomerase. TG2 is involved in cell adhesion, migration, invasion, and growth, as well as epithelial-mesenchymal transition (EMT). Our previous findings indicate that the increased expression of TG2 in renal cell carcinoma (RCC) results in tumor metastasis with a significant decrease in disease- and cancer-specific survival outcome. Given the importance of the prometastatic activity of TG2 in RCC, in the present study, we aim to investigate the relative contribution of TG2's transamidase and guanosine triphosphate (GTP)-binding/GTPase activity in the cell migration, invasion, EMT, and cancer stemness of RCC. For this purpose, the mouse RCC cell line RenCa was transduced with wild-type-TG2 (wt-TG2), GTP-binding deficient-form TG2-R580A, transamidase-deficient form with low GTP-binding affinity TG2-C277S, and transamidase-inactive form TG2-W241A. Our results suggested that predominantly, GTP-binding activity of TG2 is responsible for cell migration and invasion. In addition, CD marker analysis and spheroid assay confirmed that GTP binding/GTPase activity of TG2 is important in the maintenance of mesenchymal character and the cancer stem cell profile. These findings support a prometastatic role for TG2 in RCC that is dependent on the GTP binding/GTPase activity of the enzyme." @default.
• W3093871736 created "2020-10-29" @default.
• W3093871736 creator A5008625315 @default.
• W3093871736 creator A5010755529 @default.
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• W3093871736 creator A5078618071 @default.
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• W3093871736 date "2020-10-20" @default.
• W3093871736 modified "2023-10-13" @default.
• W3093871736 title "Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression" @default.
• W3093871736 cites W1571232771 @default.
• W3093871736 cites W1817697566 @default.
• W3093871736 cites W1852463684 @default.
• W3093871736 cites W1928799475 @default.
• W3093871736 cites W1963811337 @default.
• W3093871736 cites W1964081206 @default.
• W3093871736 cites W1965951474 @default.
• W3093871736 cites W1972823610 @default.
• W3093871736 cites W1974823430 @default.
• W3093871736 cites W1983095364 @default.
• W3093871736 cites W1989962141 @default.
• W3093871736 cites W1991697633 @default.
• W3093871736 cites W1994115546 @default.
• W3093871736 cites W1995228256 @default.
• W3093871736 cites W1996834104 @default.
• W3093871736 cites W1996889334 @default.
• W3093871736 cites W1998971716 @default.
• W3093871736 cites W2000185144 @default.
• W3093871736 cites W2009213090 @default.
• W3093871736 cites W2013291988 @default.
• W3093871736 cites W2014683547 @default.
• W3093871736 cites W2014691022 @default.
• W3093871736 cites W2020417931 @default.
• W3093871736 cites W2028593825 @default.
• W3093871736 cites W2029657029 @default.
• W3093871736 cites W2031533713 @default.
• W3093871736 cites W2038390742 @default.
• W3093871736 cites W2039071997 @default.
• W3093871736 cites W2040068921 @default.
• W3093871736 cites W2040310420 @default.
• W3093871736 cites W2041904607 @default.
• W3093871736 cites W2046815613 @default.
• W3093871736 cites W2064044053 @default.
• W3093871736 cites W2066037408 @default.
• W3093871736 cites W2066463226 @default.
• W3093871736 cites W2075972114 @default.
• W3093871736 cites W2081895505 @default.
• W3093871736 cites W2092539339 @default.
• W3093871736 cites W2095512379 @default.
• W3093871736 cites W2097831215 @default.
• W3093871736 cites W2100545793 @default.
• W3093871736 cites W2101115077 @default.
• W3093871736 cites W2109032682 @default.
• W3093871736 cites W2115847623 @default.
• W3093871736 cites W2115978612 @default.
• W3093871736 cites W2118492595 @default.
• W3093871736 cites W2118915702 @default.
• W3093871736 cites W2122451309 @default.
• W3093871736 cites W2126351542 @default.
• W3093871736 cites W2131236880 @default.
• W3093871736 cites W2135139265 @default.
• W3093871736 cites W2136595037 @default.
• W3093871736 cites W2137064432 @default.
• W3093871736 cites W2139893628 @default.
• W3093871736 cites W2143202717 @default.
• W3093871736 cites W2147464405 @default.
• W3093871736 cites W2147492777 @default.
• W3093871736 cites W2150417700 @default.
• W3093871736 cites W2150444196 @default.
• W3093871736 cites W2153899562 @default.
• W3093871736 cites W2155626821 @default.
• W3093871736 cites W2164704968 @default.
• W3093871736 cites W2166782237 @default.
• W3093871736 cites W2168215039 @default.
• W3093871736 cites W2168388492 @default.
• W3093871736 cites W2170725518 @default.
• W3093871736 cites W2193938114 @default.
• W3093871736 cites W2275445498 @default.
• W3093871736 cites W2277922850 @default.
• W3093871736 cites W2333349365 @default.
• W3093871736 cites W2336925588 @default.
• W3093871736 cites W2340332104 @default.
• W3093871736 cites W2347568526 @default.
• W3093871736 cites W2512886987 @default.
• W3093871736 cites W2537414275 @default.
• W3093871736 cites W2550247678 @default.
• W3093871736 cites W2564643093 @default.
• W3093871736 cites W2589926635 @default.
• W3093871736 cites W2613911468 @default.
• W3093871736 cites W2614480329 @default.
• W3093871736 cites W2901787067 @default.
• W3093871736 cites W3014186444 @default.
• W3093871736 cites W4299573794 @default.
• W3093871736 cites W2035207810 @default.
• W3093871736 doi "https://doi.org/10.1021/acsomega.0c04226" @default.
• W3093871736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7643270" @default.
• W3093871736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33163811" @default.
• W3093871736 hasPublicationYear "2020" @default.
• W3093871736 type Work @default.

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