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- W3093891609 abstract "Abstract Adrenoceptors are ubiquitous and mediate important autonomic functions as well as modulating arousal, cognition, and pain on a central level. Understanding these physiological processes and their underlying neural circuits requires manipulating adrenergic neurotransmission with high spatio‐temporal precision. Here we present a first generation of photochromic ligands (adrenoswitches) obtained via azologization of a class of cyclic amidines related to the known ligand clonidine. Their pharmacology, photochromism, bioavailability, and lack of toxicity allow for broad biological applications, as demonstrated by controlling locomotion in zebrafish and pupillary responses in mice." @default.
- W3093891609 created "2020-10-29" @default.
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- W3093891609 date "2020-12-21" @default.
- W3093891609 modified "2023-10-16" @default.
- W3093891609 title "Adrenergic Modulation With Photochromic Ligands" @default.
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- W3093891609 doi "https://doi.org/10.1002/anie.202010553" @default.
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