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- W3093896219 endingPage "3760" @default.
- W3093896219 startingPage "3760" @default.
- W3093896219 abstract "There are limited proven therapies for COVID-19. Vitamin C’s antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19. This literature review focuses on vitamin C deficiency in respiratory infections, including COVID-19, and the mechanisms of action in infectious disease, including support of the stress response, its role in preventing and treating colds and pneumonia, and its role in treating sepsis and COVID-19. The evidence to date indicates that oral vitamin C (2–8 g/day) may reduce the incidence and duration of respiratory infections and intravenous vitamin C (6–24 g/day) has been shown to reduce mortality, intensive care unit (ICU) and hospital stays, and time on mechanical ventilation for severe respiratory infections. Further trials are urgently warranted. Given the favourable safety profile and low cost of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it may be worthwhile testing patients’ vitamin C status and treating them accordingly with intravenous administration within ICUs and oral administration in hospitalised persons with COVID-19." @default.
- W3093896219 created "2020-10-29" @default.
- W3093896219 creator A5009974125 @default.
- W3093896219 creator A5046107108 @default.
- W3093896219 creator A5050145877 @default.
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- W3093896219 creator A5062367983 @default.
- W3093896219 creator A5063456776 @default.
- W3093896219 creator A5084627213 @default.
- W3093896219 date "2020-12-07" @default.
- W3093896219 modified "2023-10-16" @default.
- W3093896219 title "Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19" @default.
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