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- W3093941974 abstract "Membrane curvature has emerged as an intriguing physical principle underlying biological signaling and membrane trafficking. The CIP4/FBP17/Toca-1 F-BAR subfamily is unique in the BAR family because its structurally folded F-BAR domain does not contain any hydrophobic motifs that insert into membrane. Although widely assumed so, whether the banana-shaped F-BAR domain alone can sense curvature has never been experimentally demonstrated. Using a nanobar-supported lipid bilayer system, we found that the F-BAR domain of FBP17 displayed minimal curvature sensing in vitro. In comparison, an alternatively spliced intrinsically disordered region (IDR) adjacent to the F-BAR domain has the membrane curvature-sensing ability greatly exceeding that of F-BAR domain alone. In living cells, the presence of the IDR delayed the recruitment of FBP17 in curvature-coupled cortical waves. Collectively, we propose that contrary to the common belief, FBP17's curvature-sensing capability largely originates from IDR, and not the F-BAR domain alone." @default.
- W3093941974 created "2020-10-29" @default.
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- W3093941974 date "2020-11-01" @default.
- W3093941974 modified "2023-10-18" @default.
- W3093941974 title "Comparative Study of Curvature Sensing Mediated by F-BAR and an Intrinsically Disordered Region of FBP17" @default.
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- W3093941974 doi "https://doi.org/10.1016/j.isci.2020.101712" @default.
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