FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093983048> ?p ?o ?g. }

• W3093983048 endingPage "e0233938" @default.
• W3093983048 startingPage "e0233938" @default.
• W3093983048 abstract "Onion is one of the most commonly used plants in the traditional medicine for the treatment of various diseases. We recently demonstrated the anti-inflammatory properties of onion bulb extract (OBE) in reducing colitis severity in mice when administered at the same time of colitis induction. However, whether onion can reverse established colitis or even prevent its development has not been investigated.To test 1. whether OBE can reduce colitis severity when given either before (preventative approach) or after (treatment approach) colitis induction and if so, 2. what are the mechanisms by which onion can achieve these effects.Colitis was induced by dextran sulfate sodium (DSS) administration using treatment and preventative approaches. The severity of the inflammation was determined by the gross and histological assessments. The colonic level/activity of pro-inflammatory molecules and immune cell markers was assessed by immunofluorescence and western blotting analysis. In vitro neutrophil superoxide release and survival was assessed by chemilumenecense and Annexin-V/7AAD assays respectively.OBE treatment significantly reduced colitis severity in both approaches, the colonic expression/activity profile of pro-inflammatory molecules, inhibited WKYMVm-induced superoxide release, and increased spontaneous apoptosis of neutrophils in vitro.OBE can be used as an effective option in the prevention and/or the treatment of established colitis." @default.
• W3093983048 created "2020-10-29" @default.
• W3093983048 creator A5012334770 @default.
• W3093983048 creator A5016064053 @default.
• W3093983048 creator A5022972956 @default.
• W3093983048 creator A5065967997 @default.
• W3093983048 creator A5089943202 @default.
• W3093983048 date "2020-10-23" @default.
• W3093983048 modified "2023-10-12" @default.
• W3093983048 title "Onion bulb extract can both reverse and prevent colitis in mice via inhibition of pro-inflammatory signaling molecules and neutrophil activity" @default.
• W3093983048 cites W1901931884 @default.
• W3093983048 cites W1946093640 @default.
• W3093983048 cites W1979948289 @default.
• W3093983048 cites W1981714996 @default.
• W3093983048 cites W1997638368 @default.
• W3093983048 cites W2008771544 @default.
• W3093983048 cites W2022910993 @default.
• W3093983048 cites W2040206306 @default.
• W3093983048 cites W2060373663 @default.
• W3093983048 cites W2063731747 @default.
• W3093983048 cites W2069787314 @default.
• W3093983048 cites W2095645372 @default.
• W3093983048 cites W2099746528 @default.
• W3093983048 cites W2100337344 @default.
• W3093983048 cites W2107418647 @default.
• W3093983048 cites W2123210093 @default.
• W3093983048 cites W2125967107 @default.
• W3093983048 cites W2126479453 @default.
• W3093983048 cites W2126874760 @default.
• W3093983048 cites W2138584845 @default.
• W3093983048 cites W2143809776 @default.
• W3093983048 cites W2146153364 @default.
• W3093983048 cites W2151088711 @default.
• W3093983048 cites W2152803022 @default.
• W3093983048 cites W2158744241 @default.
• W3093983048 cites W2159309054 @default.
• W3093983048 cites W2165163741 @default.
• W3093983048 cites W2165655699 @default.
• W3093983048 cites W2185477872 @default.
• W3093983048 cites W2207720942 @default.
• W3093983048 cites W226354033 @default.
• W3093983048 cites W2295658637 @default.
• W3093983048 cites W2413205046 @default.
• W3093983048 cites W2467048034 @default.
• W3093983048 cites W2484297064 @default.
• W3093983048 cites W2531947224 @default.
• W3093983048 cites W2562373507 @default.
• W3093983048 cites W2569340098 @default.
• W3093983048 cites W2596536295 @default.
• W3093983048 cites W2604969316 @default.
• W3093983048 cites W2610839660 @default.
• W3093983048 cites W2732571380 @default.
• W3093983048 cites W2742824155 @default.
• W3093983048 cites W2771603440 @default.
• W3093983048 cites W2788857805 @default.
• W3093983048 cites W2795252759 @default.
• W3093983048 cites W2803683171 @default.
• W3093983048 cites W2804996673 @default.
• W3093983048 cites W2808595848 @default.
• W3093983048 cites W2885818963 @default.
• W3093983048 cites W2895269825 @default.
• W3093983048 cites W2898787183 @default.
• W3093983048 cites W2900895468 @default.
• W3093983048 cites W2904202908 @default.
• W3093983048 cites W2906019120 @default.
• W3093983048 cites W2910072039 @default.
• W3093983048 cites W2937138629 @default.
• W3093983048 cites W2947346046 @default.
• W3093983048 cites W2963228387 @default.
• W3093983048 cites W2963917196 @default.
• W3093983048 cites W2974353717 @default.
• W3093983048 cites W2996232947 @default.
• W3093983048 cites W3003661503 @default.
• W3093983048 cites W3005951776 @default.
• W3093983048 cites W3007030385 @default.
• W3093983048 cites W3007780530 @default.
• W3093983048 doi "https://doi.org/10.1371/journal.pone.0233938" @default.
• W3093983048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7584208" @default.
• W3093983048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33095803" @default.
• W3093983048 hasPublicationYear "2020" @default.
• W3093983048 type Work @default.
• W3093983048 sameAs 3093983048 @default.
• W3093983048 citedByCount "6" @default.
• W3093983048 countsByYear W30939830482021 @default.
• W3093983048 countsByYear W30939830482022 @default.
• W3093983048 countsByYear W30939830482023 @default.
• W3093983048 crossrefType "journal-article" @default.
• W3093983048 hasAuthorship W3093983048A5012334770 @default.
• W3093983048 hasAuthorship W3093983048A5016064053 @default.
• W3093983048 hasAuthorship W3093983048A5022972956 @default.
• W3093983048 hasAuthorship W3093983048A5065967997 @default.
• W3093983048 hasAuthorship W3093983048A5089943202 @default.
• W3093983048 hasBestOaLocation W30939830481 @default.
• W3093983048 hasConcept C126322002 @default.
• W3093983048 hasConcept C181199279 @default.
• W3093983048 hasConcept C185592680 @default.
• W3093983048 hasConcept C190283241 @default.
• W3093983048 hasConcept C202751555 @default.

• next