FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094002643> ?p ?o ?g. }

• W3094002643 endingPage "e661" @default.
• W3094002643 startingPage "e661" @default.
• W3094002643 abstract "Nonoperative management (NOM) is increasingly utilized for patients with locally advanced rectal cancer (LARC) who achieve a complete clinical response (cCR) to neoadjuvant therapy. Close surveillance for tumor regrowth is a mandatory component of NOM but requires a high burden of studies, and limited data exist on patient and provider compliance. This study reports compliance and early outcomes for a single institution cohort. Patients with LARC who had a cCR to neoadjuvant therapy and elected NOM from 4/2015 to 2/2020 were included. An institutional surveillance protocol was developed as follows: 1. DRE, flexible sigmoidoscopy, and CEA every 3 months for 2 years, then every 6-12 months for 5 years. Scar biopsy not required unless suspicion for regrowth 2. MRI pelvis every 6 months for 2 years, then annually for 5 years 3. CT chest/abdomen/pelvis every 12 months for 5 years Compliance was evaluated in terms of follow up retention (rate of patients meeting all indicated follow up visits), patient adherence (number of studies completed/number of studies ordered or recommended), provider adherence (number of studies ordered or recommended/number of studies indicated per protocol), overall compliance (number of studies completed/number of studies indicated per protocol), and safety (rate of salvageable local recurrences). Two-year progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan-Meier method. Twenty patients were included. All patients underwent neoadjuvant chemoradiation and 16 (80%) received neoadjuvant chemotherapy. Median follow up and time on NOM were 19 months (range, 10-57) and 11 months (1-54), respectively. Seventeen patients (85%) were retained to follow up (1 moved, 2 lost for unknown reasons). Median patient adherence was 100% (25-100), provider adherence was 81% (22-100), and overall compliance was 67% (6-100). Three patients received surveillance at outside institutions and had overall compliance rates of 6%, 47%, and 67%. When excluding these patients, median overall compliance was 80% (44-100). Two patients (10%) had local progression detected by flexible sigmoidoscopy after 3 and 20 months on NOM, respectively. Both underwent salvage surgery with no evidence of disease after an additional 5 and 4 months of follow up. One patient had distant progression detected by elevated CEA and CT c/a/p. PFS was 73% and OS was 100%. Six patients were deemed to require APR at the time of diagnosis, and 5 (of 6, 83%) were spared. In a small cohort with short follow up, this institutional NOM surveillance protocol appears to be safe with acceptable compliance rates, particularly for patients completing all surveillance at this experienced multidisciplinary cancer center. Future work involves education to improve provider adherence and development of a prospective registry to obtain data on long term outcomes, optimization of cCR rates, improved patient selection, QOL outcomes, and cost-effectiveness." @default.
• W3094002643 created "2020-10-29" @default.
• W3094002643 creator A5012289008 @default.
• W3094002643 creator A5034820767 @default.
• W3094002643 creator A5035621447 @default.
• W3094002643 creator A5041985732 @default.
• W3094002643 creator A5042043860 @default.
• W3094002643 creator A5042395174 @default.
• W3094002643 creator A5048597793 @default.
• W3094002643 creator A5056276499 @default.
• W3094002643 creator A5069715843 @default.
• W3094002643 creator A5083218831 @default.
• W3094002643 date "2020-11-01" @default.
• W3094002643 modified "2023-09-29" @default.
• W3094002643 title "Compliance and Early Outcomes for Nonoperative Management of Locally Advanced Rectal Cancer at a Single Institution" @default.
• W3094002643 doi "https://doi.org/10.1016/j.ijrobp.2020.07.1978" @default.
• W3094002643 hasPublicationYear "2020" @default.
• W3094002643 type Work @default.
• W3094002643 sameAs 3094002643 @default.
• W3094002643 citedByCount "0" @default.
• W3094002643 crossrefType "journal-article" @default.
• W3094002643 hasAuthorship W3094002643A5012289008 @default.
• W3094002643 hasAuthorship W3094002643A5034820767 @default.
• W3094002643 hasAuthorship W3094002643A5035621447 @default.
• W3094002643 hasAuthorship W3094002643A5041985732 @default.
• W3094002643 hasAuthorship W3094002643A5042043860 @default.
• W3094002643 hasAuthorship W3094002643A5042395174 @default.
• W3094002643 hasAuthorship W3094002643A5048597793 @default.
• W3094002643 hasAuthorship W3094002643A5056276499 @default.
• W3094002643 hasAuthorship W3094002643A5069715843 @default.
• W3094002643 hasAuthorship W3094002643A5083218831 @default.
• W3094002643 hasBestOaLocation W30940026431 @default.
• W3094002643 hasConcept C121608353 @default.
• W3094002643 hasConcept C126322002 @default.
• W3094002643 hasConcept C141071460 @default.
• W3094002643 hasConcept C2778292576 @default.
• W3094002643 hasConcept C2778357063 @default.
• W3094002643 hasConcept C2778435480 @default.
• W3094002643 hasConcept C2779896975 @default.
• W3094002643 hasConcept C509974204 @default.
• W3094002643 hasConcept C526805850 @default.
• W3094002643 hasConcept C530470458 @default.
• W3094002643 hasConcept C71924100 @default.
• W3094002643 hasConcept C72563966 @default.
• W3094002643 hasConceptScore W3094002643C121608353 @default.
• W3094002643 hasConceptScore W3094002643C126322002 @default.
• W3094002643 hasConceptScore W3094002643C141071460 @default.
• W3094002643 hasConceptScore W3094002643C2778292576 @default.
• W3094002643 hasConceptScore W3094002643C2778357063 @default.
• W3094002643 hasConceptScore W3094002643C2778435480 @default.
• W3094002643 hasConceptScore W3094002643C2779896975 @default.
• W3094002643 hasConceptScore W3094002643C509974204 @default.
• W3094002643 hasConceptScore W3094002643C526805850 @default.
• W3094002643 hasConceptScore W3094002643C530470458 @default.
• W3094002643 hasConceptScore W3094002643C71924100 @default.
• W3094002643 hasConceptScore W3094002643C72563966 @default.
• W3094002643 hasIssue "3" @default.
• W3094002643 hasLocation W30940026431 @default.
• W3094002643 hasOpenAccess W3094002643 @default.
• W3094002643 hasPrimaryLocation W30940026431 @default.
• W3094002643 hasRelatedWork W1974508703 @default.
• W3094002643 hasRelatedWork W2002120878 @default.
• W3094002643 hasRelatedWork W2032042555 @default.
• W3094002643 hasRelatedWork W2032209458 @default.
• W3094002643 hasRelatedWork W2047967234 @default.
• W3094002643 hasRelatedWork W2404259405 @default.
• W3094002643 hasRelatedWork W2419645855 @default.
• W3094002643 hasRelatedWork W2439875401 @default.
• W3094002643 hasRelatedWork W3029138839 @default.
• W3094002643 hasRelatedWork W3032158305 @default.
• W3094002643 hasVolume "108" @default.
• W3094002643 isParatext "false" @default.
• W3094002643 isRetracted "false" @default.
• W3094002643 magId "3094002643" @default.
• W3094002643 workType "article" @default.