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- W3094005698 abstract "Tropomyosin receptor kinase B (Trk-B) belongs to the second largest family of membrane receptors, Receptor Tyrosine Kinases (RTKs). Trk-B is known to interact with three different neurotrophins: Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin-4 (NT-4), and Neurotrophin-3 (NT-3). All three neurotrophins are involved in survival and proliferation of neuronal cells, but each induces distinct signaling through Trk-B. We hypothesize that the different biological effects correlate with differences in the interactions between the Trk-B receptors, when bound to different ligands, in the plasma membrane. To test this hypothesis, we use quantitative FRET to characterize Trk-B dimerization in response to NT-3 and NT-4 in live cells, and compare it to the previously published data for Trk-B in the absence and presence of BDNF. Our study reveals that the distinct Trk-B signaling outcomes are underpinned by both different configurations and different stabilities of the three ligand-bound Trk-B dimers in the plasma membrane." @default.
- W3094005698 created "2020-10-29" @default.
- W3094005698 creator A5000748364 @default.
- W3094005698 creator A5039892950 @default.
- W3094005698 creator A5076185298 @default.
- W3094005698 date "2020-12-03" @default.
- W3094005698 modified "2023-10-14" @default.
- W3094005698 title "The biophysical basis of receptor tyrosine kinase ligand functional selectivity: Trk-B case study" @default.
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- W3094005698 doi "https://doi.org/10.1042/bcj20200671" @default.
- W3094005698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8173487" @default.
- W3094005698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33094812" @default.
- W3094005698 hasPublicationYear "2020" @default.
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