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• W3094038502 abstract "Background. Left ventricular (LV) systolic dysfunction is common in septic shock. Global longitudinal strain (GLS) measured by speckle tracking echocardiography (STE) is a useful marker of intrinsic left ventricular systolic function. However, the association between left ventricular GLS and outcome in septic patients is not well understood. We performed this prospective study to investigate the prognostic value of LV systolic function utilizing speckle tracking echocardiography in patients with septic shock. Methods. All the patients with septic shock based on sepsis-3 definition admitted to the intensive care unit were prospectively studied with STE within 24 hours after the onset of septic shock. Baseline clinical and echocardiographic variables were collected. The primary outcome was in-hospital mortality. Results. During a 19-month period, 90 consecutive patients were enrolled in the study. The in-hospital mortality rate was 43.3%. Compared with survivors, nonsurvivors exhibited significantly less negative GLS ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mo>−</mo> <mn>13.1</mn> <mo>±</mo> <mn>3.3</mn> <mi>%</mi> </math> versus <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mo>−</mo> <mn>15.8</mn> <mo>±</mo> <mn>2.9</mn> <mi>%</mi> </math> ; <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>p</mi> <mo><</mo> <mn>0.001</mn> </math> ), which reflected worse LV systolic function. The area under the ROC curves of GLS for the prediction of mortality was 0.76 (95% CI 0.67 to 0.87). Patients with <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mtext>GLS</mtext> <mo>></mo> <mo>−</mo> <mn>14.1</mn> <mi>%</mi> </math> showed a significantly higher mortality rate (67.7% versus 15.6%; <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>p</mi> <mo><</mo> <mn>0.0001</mn> </math> ; <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <mi mathvariant=normal>log</mi> <mo>‐</mo> <mi mathvariant=normal>rank</mi> <mo>=</mo> <mn>23.3</mn> </math> ; <math xmlns=http://www.w3.org/1998/Math/MathML id=M7> <mi>p</mi> <mo><</mo> <mn>0.0001</mn> </math> ). In the multivariate analysis, GLS (HR, 1.27; 95% CI 1.07 to 1.50, <math xmlns=http://www.w3.org/1998/Math/MathML id=M8> <mi>p</mi> <mo>=</mo> <mn>0.005</mn> </math> ) and SOFA scores (HR, 1.27; 95% CI 1.08 to 1.50, <math xmlns=http://www.w3.org/1998/Math/MathML id=M9> <mi>p</mi> <mo>=</mo> <mn>0.004</mn> </math> ) were independent predictors of in-hospital mortality. Conclusions. Our study indicated that LV systolic function measured by STE might be associated with mortality in patients with septic shock." @default.
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• W3094038502 date "2020-10-21" @default.
• W3094038502 modified "2023-10-12" @default.
• W3094038502 title "Prognostic Role of Left Ventricular Systolic Function Measured by Speckle Tracking Echocardiography in Septic Shock" @default.
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• W3094038502 doi "https://doi.org/10.1155/2020/7927353" @default.
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