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- W3094043879 abstract "To develop a novel dose-averaged linear energy transfer (LETd) integrated spot-scanning proton arc therapy (SPArc) optimization algorithm and to exploit its feasibility and potential clinical benefits. An open-source proton planning platform has been modified to incorporate LETd into optimization for both SPArc and multi-field intensity-modulated proton therapy (IMPT) treatment planning. SPArc and multi-field IMPT plans with multi-beam configurations (2, 4, 6, and 8 equally spacing fields) for a prostate patient were generated to investigate the feasibility of LETd-based optimization using SPArc in terms of spatially distributing LETd and plan delivery efficiency. One liver and one brain case were also studied to further evaluate the advantages of SPArc over multi-field IMPT. With similar dose distributions, the efficacy of spatially optimizing LETd distributions improves with increasing number of beams. Compared with multi-field IMPT, SPArc shows substantial improvement in spatially LETd distributions while keeping similar delivery efficiency. Specifically, for the liver case, the average LETd in the GTV was 4.88 and 2.35 keV/μm for the SPArc and 2-field IMPT plans respectively. Compared with the 2-field non-LETd optimized IMPT plan, the LETd increased by 129% for SPArc plan, and only 12% for the LETd optimized IMPT plan due to the limited number of beams. In case of LET optimization in brain case, the average LETd for the SPArc plan was increased by 29% for CTV, and was decreased by 22%, 30%, 28%, and 17% for brainstem, chiasm, left, and right optical nerves, respectively, compared to the 3-field non-LETd optimized IMPT plan. Subsequently, smaller improvement was observed in the 3-field LETd optimized IMPT plan (4%, 12%, 22%, 21%, and -3%, respectively). This work demonstrates the feasibility and significant advantages of using SPArc with LETd-based optimization, which could maximize the LETd distribution wherever is desired inside the target and averts the high LETd away from the adjacent critical organs-at-risk." @default.
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- W3094043879 date "2020-11-01" @default.
- W3094043879 modified "2023-09-26" @default.
- W3094043879 title "A Novel Linear Energy Transfer Integrated Spot-Scanning Proton Arc Therapy Algorithm: Feasibility Study and Clinical Potential" @default.
- W3094043879 doi "https://doi.org/10.1016/j.ijrobp.2020.07.980" @default.
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