Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094047588> ?p ?o ?g. }
- W3094047588 abstract "Abstract Epigenetic dysregulation is a common mechanism shared by molecularly and clinically heterogenous neurodegenerative diseases (NDs). Histone acetylation homeostasis, maintained by the antagonistic activity of histone acetyltransferases (HATs) and histone deacetylases (HDACs), is necessary for appropriate gene expression and neuronal function. Disruption of neural acetylation homeostasis has been implicated in multiple types of NDs including Alzheimer’s disease (AD), yet mechanisms underlying alterations remain unclear. We show that like AD, disruption of Tip60 HAT/HDAC2 balance with concomitant epigenetic repression of common Tip60 target neuroplasticity genes occurs early in multiple types of Drosophila ND models such as Parkinson’s Disease (PD), Huntington’s Disease (HD) and Amyotrophic Lateral Sclerosis (ALS). Repressed neuroplasticity genes show reduced enrichment of Tip60 and epigentic acetylation signatures at all gene loci examined with certain genes showing inappropriate HDAC2 repressor enrichment. Functional neuronal consequences for these disease conditions are reminiscent of human pathology and include locomotion, synapse morphology, and short-term memory deficits. Increasing Tip60 HAT levels specifically in the mushroom body learning and memory center in the Drosophila brain protects against locomotion and short-term memory function deficits in multiple NDs. Together, our results support a model by which Tip60 protects against neurological impairments in different NDs via similar modes of action." @default.
- W3094047588 created "2020-10-29" @default.
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- W3094047588 date "2020-10-26" @default.
- W3094047588 modified "2023-10-16" @default.
- W3094047588 title "Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases" @default.
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- W3094047588 doi "https://doi.org/10.1038/s41598-020-75035-3" @default.
- W3094047588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7588445" @default.
- W3094047588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33106538" @default.
- W3094047588 hasPublicationYear "2020" @default.
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