FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094048765> ?p ?o ?g. }

• W3094048765 abstract "Abstract Mycobacterium abscessus (MAB) is a widely disseminated pathogenic non-tuberculous mycobacterium (NTM). Like with M. tuberculosis complex (MTBC), excreted / secreted (ES) proteins play an essential role for its virulence and survival inside the host. ES proteins contain highly immunogenic proteins, which are of interest for novel diagnostic assays and vaccines. Here, we used a robust bioinformatics pipeline to predict the secretome of the M. abscessus ATCC 19977 reference strain and fifteen clinical isolates belonging to all three MAB subspecies, M. abscessus subsp. abscessus , M. abscessus subsp. bolletii, and M. abscessus subsp. massiliense. We found that ~18% of the proteins encoded in the MAB genomes were predicted as secreted and that the three MAB subspecies shared > 85 % of the predicted secretomes. MAB isolates with a rough (R) colony morphotype showed larger predicted secretomes than isolates with a smooth (S) morphotype. Additionally, proteins exclusive to the secretomes of MAB R variants had higher antigenic densities than those exclusive to S variants, independently of the subspecies. For all investigated isolates, ES proteins had a significantly higher antigenic density than non-ES proteins. We identified 337 MAB ES proteins with homologues in previously investigated M. tuberculosis secretomes. Among these, 222 have previous experimental support of secretion, and some proteins showed homology with protein drug targets reported in the DrugBank database. The predicted MAB secretomes showed a higher abundance of proteins related to quorum-sensing and Mce domains as compared to MTBC indicating the importance of these pathways for MAB pathogenicity and virulence. Comparison of the predicted secretome of M. abscessus ATCC 19977 with the list of essential genes revealed that 99 secreted proteins corresponded to essential proteins required for in vitro growth. All predicted secretomes were deposited in the Secret-AAR web-server ( http://microbiomics.ibt.unam.mx/tools/aar/index.php )." @default.
• W3094048765 created "2020-10-29" @default.
• W3094048765 creator A5000918689 @default.
• W3094048765 creator A5016385354 @default.
• W3094048765 creator A5017649537 @default.
• W3094048765 creator A5019449593 @default.
• W3094048765 creator A5041222465 @default.
• W3094048765 creator A5054937250 @default.
• W3094048765 creator A5058051345 @default.
• W3094048765 creator A5063438724 @default.
• W3094048765 creator A5065671234 @default.
• W3094048765 creator A5078438280 @default.
• W3094048765 date "2020-10-22" @default.
• W3094048765 modified "2023-10-18" @default.
• W3094048765 title "In silico secretome characterization of clinical Mycobacterium abscessus isolates provides insights into antigenic differences" @default.
• W3094048765 cites W1537641994 @default.
• W3094048765 cites W1935158889 @default.
• W3094048765 cites W1981835811 @default.
• W3094048765 cites W2001338440 @default.
• W3094048765 cites W2004548026 @default.
• W3094048765 cites W2012416775 @default.
• W3094048765 cites W2022366078 @default.
• W3094048765 cites W2037921546 @default.
• W3094048765 cites W2039399915 @default.
• W3094048765 cites W2051650567 @default.
• W3094048765 cites W2052547168 @default.
• W3094048765 cites W2072708417 @default.
• W3094048765 cites W2073612072 @default.
• W3094048765 cites W2074401088 @default.
• W3094048765 cites W2076729878 @default.
• W3094048765 cites W2078178166 @default.
• W3094048765 cites W2094201044 @default.
• W3094048765 cites W2096830865 @default.
• W3094048765 cites W2098455244 @default.
• W3094048765 cites W2104325455 @default.
• W3094048765 cites W2108459792 @default.
• W3094048765 cites W2110215664 @default.
• W3094048765 cites W2116279310 @default.
• W3094048765 cites W2116788456 @default.
• W3094048765 cites W2124088653 @default.
• W3094048765 cites W2131271579 @default.
• W3094048765 cites W2131778683 @default.
• W3094048765 cites W2133274440 @default.
• W3094048765 cites W2133330626 @default.
• W3094048765 cites W2133579817 @default.
• W3094048765 cites W2136307168 @default.
• W3094048765 cites W2158450933 @default.
• W3094048765 cites W2170726218 @default.
• W3094048765 cites W2189462271 @default.
• W3094048765 cites W2201075490 @default.
• W3094048765 cites W2223993952 @default.
• W3094048765 cites W2270176699 @default.
• W3094048765 cites W2340254326 @default.
• W3094048765 cites W2506753654 @default.
• W3094048765 cites W2558222949 @default.
• W3094048765 cites W2586329336 @default.
• W3094048765 cites W2751144760 @default.
• W3094048765 cites W2762985876 @default.
• W3094048765 cites W2781862115 @default.
• W3094048765 cites W2783698286 @default.
• W3094048765 cites W2803716777 @default.
• W3094048765 cites W2897559173 @default.
• W3094048765 cites W2899469009 @default.
• W3094048765 cites W2909180420 @default.
• W3094048765 cites W2931314706 @default.
• W3094048765 cites W2952404779 @default.
• W3094048765 cites W2969057284 @default.
• W3094048765 cites W3001272310 @default.
• W3094048765 cites W206421451 @default.
• W3094048765 doi "https://doi.org/10.1101/2020.10.22.349720" @default.
• W3094048765 hasPublicationYear "2020" @default.
• W3094048765 type Work @default.
• W3094048765 sameAs 3094048765 @default.
• W3094048765 citedByCount "0" @default.
• W3094048765 crossrefType "posted-content" @default.
• W3094048765 hasAuthorship W3094048765A5000918689 @default.
• W3094048765 hasAuthorship W3094048765A5016385354 @default.
• W3094048765 hasAuthorship W3094048765A5017649537 @default.
• W3094048765 hasAuthorship W3094048765A5019449593 @default.
• W3094048765 hasAuthorship W3094048765A5041222465 @default.
• W3094048765 hasAuthorship W3094048765A5054937250 @default.
• W3094048765 hasAuthorship W3094048765A5058051345 @default.
• W3094048765 hasAuthorship W3094048765A5063438724 @default.
• W3094048765 hasAuthorship W3094048765A5065671234 @default.
• W3094048765 hasAuthorship W3094048765A5078438280 @default.
• W3094048765 hasBestOaLocation W30940487651 @default.
• W3094048765 hasConcept C104317684 @default.
• W3094048765 hasConcept C147483822 @default.
• W3094048765 hasConcept C156399914 @default.
• W3094048765 hasConcept C159654299 @default.
• W3094048765 hasConcept C2775905019 @default.
• W3094048765 hasConcept C2776111603 @default.
• W3094048765 hasConcept C2780374374 @default.
• W3094048765 hasConcept C523546767 @default.
• W3094048765 hasConcept C542903549 @default.
• W3094048765 hasConcept C54355233 @default.
• W3094048765 hasConcept C60987743 @default.
• W3094048765 hasConcept C86803240 @default.
• W3094048765 hasConcept C89423630 @default.
• W3094048765 hasConceptScore W3094048765C104317684 @default.

• next