Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094073726> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W3094073726 endingPage "7779" @default.
- W3094073726 startingPage "7774" @default.
- W3094073726 abstract "Virus-like particles (VLPs) are considered useful tools for vaccine development because they induce an immune response and are safe. In addition, VLPs may be useful as a platform for the presentation of foreign antigens to elicit immune responses. In this study, we aimed to produce a chimeric VLP composed of L1 protein of bovine papillomavirus type 6 (BPV6-L1) that can display an entire foreign protein on its surface. Based on prediction of the conformational structure of VLP of BPV6-L1 (BPV6-VLP), candidate insertion sites for the foreign protein into BPV6-VLP were identified. Fusion proteins of BPV6-L1 and EGFP as a model foreign protein were constructed and produced. Only the fusion protein in which EGFP was inserted between amino acids 136 and 137 of BPV6-L1 self-assembled into VLPs and did not exhibit hindrance of the conformation of EGFP. Chimeric BPV6-VLP-immunized mice produced specific IgG against both BPV6 and EGFP. This is the first demonstration of the production of an immunogenic, bivalent, chimeric BPV6-VLP incorporating an entire protein for stable surface display. Thus, immunogenic chimeric BPV6-VLP may constitute a promising vaccine platform." @default.
- W3094073726 created "2020-10-29" @default.
- W3094073726 creator A5058984801 @default.
- W3094073726 creator A5063953413 @default.
- W3094073726 creator A5064274474 @default.
- W3094073726 date "2020-11-01" @default.
- W3094073726 modified "2023-09-23" @default.
- W3094073726 title "Development of immunogenic chimeric virus-like particles based on bovine papillomavirus type 6" @default.
- W3094073726 cites W1519883411 @default.
- W3094073726 cites W1853530196 @default.
- W3094073726 cites W1973749450 @default.
- W3094073726 cites W1983507701 @default.
- W3094073726 cites W1990068438 @default.
- W3094073726 cites W1994784181 @default.
- W3094073726 cites W2001153656 @default.
- W3094073726 cites W2002141015 @default.
- W3094073726 cites W2023179470 @default.
- W3094073726 cites W2049095033 @default.
- W3094073726 cites W2074063726 @default.
- W3094073726 cites W2075515367 @default.
- W3094073726 cites W2078393115 @default.
- W3094073726 cites W2099660384 @default.
- W3094073726 cites W2115202121 @default.
- W3094073726 cites W2134278392 @default.
- W3094073726 cites W2136124026 @default.
- W3094073726 cites W2139780320 @default.
- W3094073726 cites W2144081223 @default.
- W3094073726 cites W2311192572 @default.
- W3094073726 cites W2410044662 @default.
- W3094073726 cites W2753625339 @default.
- W3094073726 cites W2792074753 @default.
- W3094073726 cites W2808156774 @default.
- W3094073726 cites W2905382880 @default.
- W3094073726 cites W4211196614 @default.
- W3094073726 doi "https://doi.org/10.1016/j.vaccine.2020.10.037" @default.
- W3094073726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33164801" @default.
- W3094073726 hasPublicationYear "2020" @default.
- W3094073726 type Work @default.
- W3094073726 sameAs 3094073726 @default.
- W3094073726 citedByCount "2" @default.
- W3094073726 countsByYear W30940737262023 @default.
- W3094073726 crossrefType "journal-article" @default.
- W3094073726 hasAuthorship W3094073726A5058984801 @default.
- W3094073726 hasAuthorship W3094073726A5063953413 @default.
- W3094073726 hasAuthorship W3094073726A5064274474 @default.
- W3094073726 hasConcept C104317684 @default.
- W3094073726 hasConcept C141231307 @default.
- W3094073726 hasConcept C159047783 @default.
- W3094073726 hasConcept C2522874641 @default.
- W3094073726 hasConcept C2776781592 @default.
- W3094073726 hasConcept C54355233 @default.
- W3094073726 hasConcept C86803240 @default.
- W3094073726 hasConcept C89423630 @default.
- W3094073726 hasConceptScore W3094073726C104317684 @default.
- W3094073726 hasConceptScore W3094073726C141231307 @default.
- W3094073726 hasConceptScore W3094073726C159047783 @default.
- W3094073726 hasConceptScore W3094073726C2522874641 @default.
- W3094073726 hasConceptScore W3094073726C2776781592 @default.
- W3094073726 hasConceptScore W3094073726C54355233 @default.
- W3094073726 hasConceptScore W3094073726C86803240 @default.
- W3094073726 hasConceptScore W3094073726C89423630 @default.
- W3094073726 hasIssue "49" @default.
- W3094073726 hasLocation W30940737261 @default.
- W3094073726 hasOpenAccess W3094073726 @default.
- W3094073726 hasPrimaryLocation W30940737261 @default.
- W3094073726 hasRelatedWork W1702322095 @default.
- W3094073726 hasRelatedWork W1865764402 @default.
- W3094073726 hasRelatedWork W1975114493 @default.
- W3094073726 hasRelatedWork W2016551366 @default.
- W3094073726 hasRelatedWork W2118087741 @default.
- W3094073726 hasRelatedWork W2121676840 @default.
- W3094073726 hasRelatedWork W2138564085 @default.
- W3094073726 hasRelatedWork W2142062823 @default.
- W3094073726 hasRelatedWork W2400613564 @default.
- W3094073726 hasRelatedWork W3029386773 @default.
- W3094073726 hasVolume "38" @default.
- W3094073726 isParatext "false" @default.
- W3094073726 isRetracted "false" @default.
- W3094073726 magId "3094073726" @default.
- W3094073726 workType "article" @default.