Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094114338> ?p ?o ?g. }
- W3094114338 abstract "In the hippocampus, a widely accepted model posits that the dentate gyrus improves learning and memory by enhancing discrimination between inputs. To test this model, we studied conditional knockout mice in which the vast majority of dentate granule cells (DGCs) fail to develop – including nearly all DGCs in the dorsal hippocampus – secondary to eliminating Wntless ( Wls ) in a subset of cortical progenitors with Gfap-Cre . Other cells in the Wls fl/- ;Gfap-Cre hippocampus were minimally affected, as determined by single nucleus RNA sequencing. CA3 pyramidal cells, the targets of DGC-derived mossy fibers, exhibited normal morphologies with a small reduction in the numbers of synaptic spines. Wls fl/- ;Gfap-Cre mice have a modest performance decrement in several complex spatial tasks, including active place avoidance. They were also modestly impaired in one simpler spatial task, finding a visible platform in the Morris water maze. These experiments support a role for DGCs in enhancing spatial learning and memory." @default.
- W3094114338 created "2020-10-29" @default.
- W3094114338 creator A5006799256 @default.
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- W3094114338 date "2020-10-21" @default.
- W3094114338 modified "2023-10-17" @default.
- W3094114338 title "Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus" @default.
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