FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094123009> ?p ?o ?g. }

• W3094123009 endingPage "925" @default.
• W3094123009 startingPage "911" @default.
• W3094123009 abstract "The results of the present study establish the temporal pattern of age-related vascular dysfunction across the adult lifespan in sedentary mice consuming a non-Western diet, and the underlying mechanisms The results demonstrate that consuming a Western diet accelerates and exacerbates vascular ageing across the lifespan in sedentary mice They also show that lifelong voluntary aerobic exercise has remarkable protective effects on vascular function throughout the lifespan, in the setting of ageing alone, as well as ageing compounded by Western diet consumption Overall, the results indicate that amelioration of mitochondrial oxidative stress and inflammation are key mechanisms underlying the voluntary aerobic exercise-associated preservation of vascular function across the lifespan in both the presence and absence of a Western dietary pattern ABSTRACT: Advancing age is the major risk factor for cardiovascular diseases, driven largely by vascular endothelial dysfunction (impaired endothelium-dependent dilatation, EDD) and aortic stiffening (increased aortic pulse wave velocity, aPWV). In humans, vascular ageing occurs in the presence of differences in diet and physical activity, but the interactive effects of these factors are unknown. We assessed carotid artery EDD and aPWV across the lifespan in mice consuming standard (normal) low-fat chow (NC) or a high-fat/high-sucrose Western diet (WD) in the absence (sedentary, SED) or presence (voluntary wheel running, VWR) of aerobic exercise. Ageing impaired nitric oxide-mediated EDD (peak EDD 88 ± 12% 6 months P = 0.003 vs. 59 ± 9% 27 months NC-SED), which was accelerated by WD (60 ± 18% 6 months WD-SED). In NC mice, aPWV increased 32% with age (423 ± 13 cm/s at 24 months P < 0.001 vs. 321 ± 12 cm/s at 6 months) and absolute values were an additional ∼10% higher at any age in WD mice (P = 0.042 vs. NC-SED). Increases in aPWV with age in NC and WD mice were associated with 30-65% increases in aortic intrinsic wall stiffness (6 vs. 19-27 months, P = 0.007). Lifelong aerobic exercise prevented age- and WD-related vascular dysfunction across the lifespan, and this protection appeared to be mediated by mitigation of vascular mitochondrial oxidative stress and inflammation. Our results depict the temporal impairment of vascular function over the lifespan in mice, acceleration and exacerbation of that dysfunction with WD consumption, the remarkable protective effects of voluntary aerobic exercise, and the underlying mechanisms." @default.
• W3094123009 created "2020-10-29" @default.
• W3094123009 creator A5001348940 @default.
• W3094123009 creator A5020452533 @default.
• W3094123009 creator A5029081520 @default.
• W3094123009 creator A5048393954 @default.
• W3094123009 creator A5050607496 @default.
• W3094123009 creator A5053802979 @default.
• W3094123009 creator A5065944938 @default.
• W3094123009 creator A5074434157 @default.
• W3094123009 creator A5076448132 @default.
• W3094123009 creator A5084597682 @default.
• W3094123009 creator A5091792035 @default.
• W3094123009 date "2020-10-28" @default.
• W3094123009 modified "2023-10-16" @default.
• W3094123009 title "Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐ induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice" @default.
• W3094123009 cites W1492660023 @default.
• W3094123009 cites W1559904992 @default.
• W3094123009 cites W1586585173 @default.
• W3094123009 cites W1591032344 @default.
• W3094123009 cites W1592269854 @default.
• W3094123009 cites W1771974095 @default.
• W3094123009 cites W1841168474 @default.
• W3094123009 cites W1946826431 @default.
• W3094123009 cites W1966355383 @default.
• W3094123009 cites W1971651068 @default.
• W3094123009 cites W1983517274 @default.
• W3094123009 cites W1983986440 @default.
• W3094123009 cites W1984257709 @default.
• W3094123009 cites W1988743087 @default.
• W3094123009 cites W1992453950 @default.
• W3094123009 cites W2015497750 @default.
• W3094123009 cites W2018078121 @default.
• W3094123009 cites W2025782661 @default.
• W3094123009 cites W2037365395 @default.
• W3094123009 cites W2038273086 @default.
• W3094123009 cites W2041077485 @default.
• W3094123009 cites W2041293047 @default.
• W3094123009 cites W2041333533 @default.
• W3094123009 cites W2042137708 @default.
• W3094123009 cites W2045378100 @default.
• W3094123009 cites W2045569660 @default.
• W3094123009 cites W2058312214 @default.
• W3094123009 cites W2060667937 @default.
• W3094123009 cites W2061658525 @default.
• W3094123009 cites W2062459662 @default.
• W3094123009 cites W2070326850 @default.
• W3094123009 cites W2077209790 @default.
• W3094123009 cites W2088920147 @default.
• W3094123009 cites W2090627862 @default.
• W3094123009 cites W2091848328 @default.
• W3094123009 cites W2097443346 @default.
• W3094123009 cites W2104842795 @default.
• W3094123009 cites W2105169259 @default.
• W3094123009 cites W2105537673 @default.
• W3094123009 cites W2106421705 @default.
• W3094123009 cites W2107886181 @default.
• W3094123009 cites W2113568840 @default.
• W3094123009 cites W2121930919 @default.
• W3094123009 cites W2122073743 @default.
• W3094123009 cites W2122341572 @default.
• W3094123009 cites W2122880159 @default.
• W3094123009 cites W2125121177 @default.
• W3094123009 cites W2136503561 @default.
• W3094123009 cites W2137121558 @default.
• W3094123009 cites W2143691602 @default.
• W3094123009 cites W2145200932 @default.
• W3094123009 cites W2149136975 @default.
• W3094123009 cites W2154395283 @default.
• W3094123009 cites W2155336691 @default.
• W3094123009 cites W2161841978 @default.
• W3094123009 cites W2162583612 @default.
• W3094123009 cites W2163261367 @default.
• W3094123009 cites W2164979547 @default.
• W3094123009 cites W2165400827 @default.
• W3094123009 cites W2166665077 @default.
• W3094123009 cites W2167755104 @default.
• W3094123009 cites W2168072390 @default.
• W3094123009 cites W2171435588 @default.
• W3094123009 cites W2182591962 @default.
• W3094123009 cites W2425349803 @default.
• W3094123009 cites W2551508804 @default.
• W3094123009 cites W2766679931 @default.
• W3094123009 cites W2767187375 @default.
• W3094123009 cites W2768726607 @default.
• W3094123009 cites W2780111846 @default.
• W3094123009 cites W2783517511 @default.
• W3094123009 cites W2802003829 @default.
• W3094123009 cites W2810260294 @default.
• W3094123009 cites W2883376857 @default.
• W3094123009 cites W2889787078 @default.
• W3094123009 cites W2891919070 @default.
• W3094123009 cites W2892475741 @default.
• W3094123009 cites W2919820141 @default.
• W3094123009 cites W2989807664 @default.
• W3094123009 cites W2995889897 @default.
• W3094123009 cites W3003299879 @default.
• W3094123009 cites W3015544325 @default.

• next