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• W3094138840 endingPage "101703" @default.
• W3094138840 startingPage "101703" @default.
• W3094138840 abstract "Oncological treatment has been revolutionised by the advent of immune checkpoint inhibitors (ICPi), which block inhibitory immune pathways to enhance anti-tumour responses and improve survival. This mode of action is non-specific so can cause immune-related adverse events, of which diarrhoea and enterocolitis are amongst the most common. ICPi-enterocolitis frequently leads to cancer therapy interruption. ICPi-gastritis typically occurs at a later stage of ICPi therapy and can present more insidiously with nausea and vomiting. ICPi-enterocolitis and gastritis are treated with corticosteroids, with refractory cases typically requiring biologic therapy. This review will briefly consider the pathogenesis of ICPi-induced GI disease, before focussing on the practical management of these conditions. The anticipated global increase in ICPi use across cancer types highlights the importance of prospective research in order that we can understand the immuno-microbiology of ICPi-enterocolitis and gastritis. This will lead to predictive biomarkers and help to define optimal treatment regimens." @default.
• W3094138840 created "2020-10-29" @default.
• W3094138840 creator A5022443019 @default.
• W3094138840 creator A5069131028 @default.
• W3094138840 date "2020-10-01" @default.
• W3094138840 modified "2023-10-13" @default.
• W3094138840 title "Immunotherapy induced enterocolitis and gastritis – What to do and when?" @default.
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• W3094138840 doi "https://doi.org/10.1016/j.bpg.2020.101703" @default.
• W3094138840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33317787" @default.
• W3094138840 hasPublicationYear "2020" @default.

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