Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094149895> ?p ?o ?g. }
- W3094149895 endingPage "594" @default.
- W3094149895 startingPage "585" @default.
- W3094149895 abstract "Background Roux-en-Y gastric bypass (RYGB) surgery is an effective treatment for obesity, which improves cardiovascular health and reduces the risk of premature mortality. However, some reports have suggested that RYGB may predispose patients to adverse health outcomes, such as inflammatory bowel disease (IBD) and colorectal cancer. Objectives The present prospective study aimed to evaluate the impact of RYGB surgery on cardiovascular risk factors and gastrointestinal inflammation in individuals with and without type 2 diabetes (T2D). Setting University hospital setting in Finland. Methods Blood and fecal samples were collected at baseline and 6 months after surgery from 30 individuals, of which 16 had T2D and 14 were nondiabetics. There were also single study visits for 6 healthy reference patients. Changes in cardiovascular risk factors, serum cholesterol, and triglycerides were investigated before and after surgery. Fecal samples were analyzed for calprotectin, anti-Saccharomyces cerevisiae immunoglobulin A antibodies (ASCA), active lipopolysaccharide (LPS) concentration, short-chain fatty acids (SCFAs), intestinal alkaline phosphatase activity, and methylglyoxal-hydro-imidazolone (MG-H1) protein adducts formation. Results After RYGB, weight decreased on average −21.6% (−27.2 ± 7.8 kg), excess weight loss averaged 51%, and there were improvements in cardiovascular risk factors. Fecal calprotectin levels (P < .001), active LPS concentration (P < .002), ASCA (P < .02), and MG-H1 (P < .02) values increased significantly, whereas fecal SCFAs, especially acetate (P < .002) and butyrate (P < .03) levels, were significantly lowered. Conclusion The intestinal homeostasis is altered after RYGB, with several fecal markers suggesting increased inflammation; however, clinical significance of the detected changes is currently uncertain. As chronic inflammation may predispose patients to adverse health effects, our findings may have relevance for the suggested association between RYGB and increased risks of incident IBD and colorectal cancer." @default.
- W3094149895 created "2020-10-29" @default.
- W3094149895 creator A5013005383 @default.
- W3094149895 creator A5023819754 @default.
- W3094149895 creator A5025549582 @default.
- W3094149895 creator A5025610737 @default.
- W3094149895 creator A5046264505 @default.
- W3094149895 creator A5050221448 @default.
- W3094149895 creator A5068788008 @default.
- W3094149895 creator A5070780036 @default.
- W3094149895 creator A5084023430 @default.
- W3094149895 creator A5084607207 @default.
- W3094149895 date "2021-03-01" @default.
- W3094149895 modified "2023-10-12" @default.
- W3094149895 title "Gastrointestinal manifestations after Roux-en-Y gastric bypass surgery in individuals with and without type 2 diabetes" @default.
- W3094149895 cites W1843464626 @default.
- W3094149895 cites W1967165953 @default.
- W3094149895 cites W1976495504 @default.
- W3094149895 cites W1976572520 @default.
- W3094149895 cites W1984993963 @default.
- W3094149895 cites W1985684171 @default.
- W3094149895 cites W1990699868 @default.
- W3094149895 cites W2004864469 @default.
- W3094149895 cites W2016075017 @default.
- W3094149895 cites W2045431945 @default.
- W3094149895 cites W2049104465 @default.
- W3094149895 cites W2060422015 @default.
- W3094149895 cites W2072657164 @default.
- W3094149895 cites W2083344098 @default.
- W3094149895 cites W2084793748 @default.
- W3094149895 cites W2089923976 @default.
- W3094149895 cites W2090440324 @default.
- W3094149895 cites W2098874583 @default.
- W3094149895 cites W2099998572 @default.
- W3094149895 cites W2103218211 @default.
- W3094149895 cites W2104183837 @default.
- W3094149895 cites W2145729618 @default.
- W3094149895 cites W2155185912 @default.
- W3094149895 cites W2202059093 @default.
- W3094149895 cites W2275206252 @default.
- W3094149895 cites W2302276483 @default.
- W3094149895 cites W2339963115 @default.
- W3094149895 cites W2344885638 @default.
- W3094149895 cites W2397597581 @default.
- W3094149895 cites W2444204414 @default.
- W3094149895 cites W2521868986 @default.
- W3094149895 cites W2553481861 @default.
- W3094149895 cites W2590939865 @default.
- W3094149895 cites W2607006009 @default.
- W3094149895 cites W2619025168 @default.
- W3094149895 cites W2622101156 @default.
- W3094149895 cites W2744935769 @default.
- W3094149895 cites W2754674511 @default.
- W3094149895 cites W2760432946 @default.
- W3094149895 cites W2767091412 @default.
- W3094149895 cites W2777221657 @default.
- W3094149895 cites W2777913435 @default.
- W3094149895 cites W2794206596 @default.
- W3094149895 cites W2808516166 @default.
- W3094149895 cites W2883586088 @default.
- W3094149895 cites W2884166738 @default.
- W3094149895 cites W2900205080 @default.
- W3094149895 cites W2910500554 @default.
- W3094149895 cites W2921966151 @default.
- W3094149895 cites W2944880600 @default.
- W3094149895 cites W2945009338 @default.
- W3094149895 cites W2963049843 @default.
- W3094149895 cites W3019058605 @default.
- W3094149895 cites W4312964893 @default.
- W3094149895 doi "https://doi.org/10.1016/j.soard.2020.10.021" @default.
- W3094149895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33246847" @default.
- W3094149895 hasPublicationYear "2021" @default.
- W3094149895 type Work @default.
- W3094149895 sameAs 3094149895 @default.
- W3094149895 citedByCount "10" @default.
- W3094149895 countsByYear W30941498952021 @default.
- W3094149895 countsByYear W30941498952022 @default.
- W3094149895 countsByYear W30941498952023 @default.
- W3094149895 crossrefType "journal-article" @default.
- W3094149895 hasAuthorship W3094149895A5013005383 @default.
- W3094149895 hasAuthorship W3094149895A5023819754 @default.
- W3094149895 hasAuthorship W3094149895A5025549582 @default.
- W3094149895 hasAuthorship W3094149895A5025610737 @default.
- W3094149895 hasAuthorship W3094149895A5046264505 @default.
- W3094149895 hasAuthorship W3094149895A5050221448 @default.
- W3094149895 hasAuthorship W3094149895A5068788008 @default.
- W3094149895 hasAuthorship W3094149895A5070780036 @default.
- W3094149895 hasAuthorship W3094149895A5084023430 @default.
- W3094149895 hasAuthorship W3094149895A5084607207 @default.
- W3094149895 hasBestOaLocation W30941498952 @default.
- W3094149895 hasConcept C126322002 @default.
- W3094149895 hasConcept C134018914 @default.
- W3094149895 hasConcept C188816634 @default.
- W3094149895 hasConcept C2777180221 @default.
- W3094149895 hasConcept C2778260677 @default.
- W3094149895 hasConcept C2778292693 @default.
- W3094149895 hasConcept C2779134260 @default.
- W3094149895 hasConcept C2779400339 @default.